Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.625 5-Year IF: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2014011320
pages 205-218

Curative Effect of Amorphophallus campanulatus (Roxb.) Blume. Tuber On N-Nitrosodiethylamine- Induced Hepatocellular Carcinoma in Rats

Puthuparampil Nazarudeen Ansil
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India
Anand Nitha
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India
Santhibhavan Prabhakaran Prabha
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India
Mukalel Sankunni Latha
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India

ABSTRACT

In this study, we investigated the curative effect of Amorphophallus campanulatus tuber methanolic extract (ACME) on N-nitrosodiethylamine (NDEA)−induced hepatocellular carcinoma (HCC) in experimental rats. All of the rats except those in the normal control group received 0.02% NDEA orally (2 mL, 5 days/week) for the first 20 weeks of the experiment. In different treatment groups, after 20 weeks of NDEA challenge, rats were supplemented with ACME (125 and 250 mg/kg body weight, orally) for the following 28 days. In addition, a standard drug control group was supplemented with silymarin (100 mg/kg bw, orally), a known tumorsuppressive agent against HCC. Administration of ACME significantly inhibited the NDEA-induced increase of hepatic nodule incidence, nodule multiplicity, and serum biochemical indices, and improved the hepatocellular architecture in a dose-dependent manner. The biochemical analysis of hepatic tissues further demonstrated that ACME counteracts NDEA-induced oxidative stress through the restoration of antioxidant enzymes. NDEAadministered rats also showed amplified expression of proliferating cell nuclear antigen in the liver, and decreased expression of this proliferative marker was clearly observed upon the supplementation of ACME. Notably, 250 mg/kg bw ACME supplementation showed better results than the other treatment regimens; this result might be associated with the enhancement of antioxidant activity and inhibition of hepatic cell proliferation.


Articles with similar content:

Malvidin Abrogates Oxidative Stress and Inflammatory Mediators to Inhibit Solid and Ascitic Tumor Development in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 3
Durairaj Brindha, Krishnamoorthy Kokilavani, Chinnadurai Kathirvelan, Kunnathur Murugesan Sakthivel
Vinblastine-Induced Cytogenotoxicity in Spermatogonia and Its Transmission in the Germline Cells of Swiss Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 2
Ramesh C. Choudhury, Rabi S. Pandit, Anil K. Palo
Naringenin Ameliorates Doxorubicin Toxicity and Hypoxic Condition in Dalton's Lymphoma Ascites Tumor Mouse Model: Evidence from Electron Paramagnetic Resonance Imaging
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 3
Kumaresan Ganesan, Venkatesan Kathiresan, Murugesan Ramachandran, Swathika Subburaman, Mathivanan Natarajan, Arun Venkatesh Krishna, Gandhidasan Rathinasamy
High Immunomodulatory and Preventive Effects Against Sarcoma 180 in Mice Fed with Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelium
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 1
Raffaello Di Bernardi, Rosalia Rubel, Jose Hermenio Cavalcante Lima Filho, Carlos Ricardo Soccol, Luiz Claudio Fernandes, Andrea N. Moreno, Fan Leifa, Herta Stutz Dalla Santa, Bonald Cavalcante Figueiredo
Pharmacological Investigation of Ceraceomyces tessulatus (Agaricomycetes) in Mice with Nonalcoholic Steatohepatitis
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 7
Vengadeshprabhu Karuppagounder, Remya Sreedhar, Somasundaram Arumugam, Kenichi Watanabe, Meilei Harima, Rejina Afrin, Xavier Alexander, Ravichandiran Velayutham