Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
Indexed in
Curative Effect of Amorphophallus campanulatus (Roxb.) Blume. Tuber On N-Nitrosodiethylamine- Induced Hepatocellular Carcinoma in Rats
ABSTRACT
In this study, we investigated the curative effect of Amorphophallus campanulatus tuber methanolic extract (ACME) on N-nitrosodiethylamine (NDEA)−induced hepatocellular carcinoma (HCC) in experimental rats. All of the rats except those in the normal control group received 0.02% NDEA orally (2 mL, 5 days/week) for the first 20 weeks of the experiment. In different treatment groups, after 20 weeks of NDEA challenge, rats were supplemented with ACME (125 and 250 mg/kg body weight, orally) for the following 28 days. In addition, a standard drug control group was supplemented with silymarin (100 mg/kg bw, orally), a known tumorsuppressive agent against HCC. Administration of ACME significantly inhibited the NDEA-induced increase of hepatic nodule incidence, nodule multiplicity, and serum biochemical indices, and improved the hepatocellular architecture in a dose-dependent manner. The biochemical analysis of hepatic tissues further demonstrated that ACME counteracts NDEA-induced oxidative stress through the restoration of antioxidant enzymes. NDEAadministered rats also showed amplified expression of proliferating cell nuclear antigen in the liver, and decreased expression of this proliferative marker was clearly observed upon the supplementation of ACME. Notably, 250 mg/kg bw ACME supplementation showed better results than the other treatment regimens; this result might be associated with the enhancement of antioxidant activity and inhibition of hepatic cell proliferation.
-
Chen Xi, Yuan Lin-Qing, Li Lin-Jie, Lv Yao, Chen Pei-Feng, Pan Lei, Suppression of gastric cancer by extract from the tuber of amorphophallus konjac via induction of apoptosis and autophagy, Oncology Reports, 38, 2, 2017. Crossref
-
Ding Yong-fang, Peng Zi-xuan, Ding Lan, Peng Yun-ru, Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway, Frontiers in Pharmacology, 10, 2019. Crossref
-
Li Jun-yi, Sun Fei, Zhou Hai-feng, Yang Jia, Huang Cong, Fan Heng, A Systematic Review Exploring the Anticancer Activity and Mechanisms of Glucomannan, Frontiers in Pharmacology, 10, 2019. Crossref
-
Sawai Sakunie, Ahmad Shukri Nursyahirah, Mohktar Mas Sahidayana, Wan Kamarul Zaman Wan Safwani, Dielectrophoresis-based discrimination of hepatic carcinoma cells following treatment with cytotoxic agents, Engineering Science and Technology, an International Journal, 25, 2022. Crossref
-
Ahmadi Nioosha, Jahantigh Hamid Reza, Noorbazargan Hassan, Yazdi Mohammad Hossein, Mahdavi Mehdi, Glucomannan as a Dietary Supplement for Treatment of Breast Cancer in a Mouse Model, Vaccines, 10, 10, 2022. Crossref