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Journal of Environmental Pathology, Toxicology and Oncology

Impact factor: 1.246

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2014010317
pages 195-204

Naringenin, a Citrus Flavonoid, Ameliorates Arsenic-Induced Toxicity in Swiss Albino Mice

Amrita Roy
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Avratanu Das
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Ruma Das
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Sagnik Haldar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Sanjib Bhattacharya
Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana 142021, Punjab, India
Pallab Kanti Haldar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India

ABSTRACT

In the present study, we evaluated the ameliorative potential of a citrus flavonoid, naringenin (NRG), against experimentally induced arsenic toxicity in Swiss albino mice. NRG (5 and 10 mg kg−l) was administered orally to mice 30 minutes before oral administration of arsenic trioxide (3 mg kg−l) for 14 consecutive days. On day 15, the following parameters were evaluated: body weight; organ weight; hematological profile; serum biochemical profile; hepatic and renal tissue antioxidative parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase levels; and DNA fragmentation. Co-treatment with NRG markedly and significantly normalized body weights, organ weights, hematological profiles, and serum biochemical profiles and significantly modulated all of the hepatic and renal tissue biochemical parameters and DNA fragmentation in arsenic-intoxicated mice. The present findings indicate that naringenin remarkably ameliorated the effects of arsenic-induced toxicity in albino mice due to its strong antioxidant property.