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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Hepatoprotective and Immunosuppressive Effect of Synedrella nodiflora L. on Carbon Tetrachloride (CCl4)-Intoxicated Rats

Volume 35, Issue 1, 2016, pp. 29-42
DOI: 10.1615/JEnvironPatholToxicolOncol.2016013802
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ABSTRACT

Synedrella nodiflora is a medicinal plant that is used by the natives of Sabah, Malaysia to treat rheumatism and several other ailments. This study aims to evaluate the ability of the crude aqueous extract of S. nodiflora leaves to protect against carbon tetrachloride (CCl4)-mediated hepatic injury in rats. S. nodiflora aqueous extract was orally administered to adult Sprague Dawley rats once daily for 14 days (150 and 300 mg/kg body weight [b.w.]) before CCl4 oral treatment (1.0 mL/kg b.w.) on the 13th and 14th days. Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), hepatic antioxidant enzymes, and malondialdehyde (MDA) levels were estimated. Immunohistochemistry was performed for oxidative stress markers (4-hydroxynonenal [HNE], 8-hydroxy-deoxyguanosine [8-OHdG]) and proinflammatory markers (tumor necrosis factor-α, interleukin-6, prostaglandin E2). Biochemical, immunohistochemical, histological, and ultrastructural findings were in agreement to support the hepatoprotective effect of S. nodiflora against CCl4-mediated oxidative hepatic damage. Hepatoprotective effects of S. nodiflora might be attributable to the presence of phenolic antioxidants and their free radical scavenging property.

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  1. Rahman A, Vasenwala SM, Iqbal M, Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats, Human & Experimental Toxicology, 36, 8, 2017. Crossref

  2. Niu Y., He J.T., Zhao Y.W., Gan Z.D., Shen M.M., Zhang L.L., Wang T., Dietary enzymatically treated Artemisia annua L. supplementation improved growth performance and intestinal antioxidant capacity of weaned piglets, Livestock Science, 232, 2020. Crossref

  3. Anyasor Godswill Nduka, Moses Nwobi, Kale Oluwafemi, Hepatoprotective and hematological effects ofJusticia secundaVahl leaves on carbon tetrachloride induced toxicity in rats, Biotechnic & Histochemistry, 95, 5, 2020. Crossref

  4. Thanebal Shameenii A/P.P., Vun-Sang Senty, Iqbal Mohammad, Hepatoprotective effects of Pandanus amaryllifolius against carbon tetrachloride (CCl4) induced toxicity: A biochemical and histopathological study, Arabian Journal of Chemistry, 14, 10, 2021. Crossref

  5. Vun-Sang Senty, Rodrigues Kenneth Francis, Dsouza Urban J. A., Iqbal Mohammad, Suppression of Oxidative Stress and Proinflammatory Cytokines Is a Potential Therapeutic Action of Ficus lepicarpa B. (Moraceae) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats, Molecules, 27, 8, 2022. Crossref

  6. Venmathi Maran Balu Alagar, Iqbal Mohammad, Gangadaran Prakash, Ahn Byeong-Cheol, Rao Pasupuleti Visweswara, Shah Muhammad Dawood, Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms, Molecules, 27, 5, 2022. Crossref

  7. Ahmed Ayesha Rahman, Ahmed Mahiba, Vun-Sang Senty, Iqbal Mohammad, Is Glyceryl Trinitrate, a Nitric Oxide Donor Responsible for Ameliorating the Chemical-Induced Tissue Injury In Vivo?, Molecules, 27, 14, 2022. Crossref

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