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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Insulin Protects against Brain Oxidative Stress with an Apparent Effect on Episodic Memory in Doxorubicin-Induced Cognitive Dysfunction in Wistar Rats

Volume 36, Issue 2, 2017, pp. 121-130
DOI: 10.1615/JEnvironPatholToxicolOncol.2017017087
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ABSTRACT

The present study was aimed at assessing the protective effect of insulin against doxorubicin (DOX)-induced cognitive dysfunction in Wistar rats. Cognitive function for episodic memory was assessed by a novel object recognition task (NORT) in male Wistar rats. Oxidative stress markers−SOD, catalase, glutathione, and lipid peroxidation−in the hippocampus and frontal cortex were assessed using colorimetric methods. Doxorubicin treatment (2.5 mg/kg, i.p., every 5 days for 50 days) reduced recognition and discriminative indices in NORT with increased oxidative stress in the brain. A nonhypoglycemic dose of insulin (0.5 IU/kg, i.p.) significantly reduced brain oxidative stress (MDA) induced by doxorubicin with an increase in the antioxidant defense systems (SOD, catalase, and GSH). Rats treated with combined insulin and DOX spent comparatively more time with the novel object when compared to the non-novel objects; however, the observed difference was not statistically significant. An apparent improvement (p < 0.26) in recognition of the novel object was observed against the damage induced by doxorubicin. These results suggest that insulin reduces brain oxidative stress and apparently improves doxorubicin-induced cognitive dysfunction in Wistar rats.

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  1. Kim Yu, Jeong Soo-Jin, Seo Chang-Seob, Lim Hye-Sun, Sohn Eunjin, Yun Jiyeon, Kim Bu-Yeo, Simultaneous Determination of the Traditional Herbal Formula Ukgansan and the In Vitro Antioxidant Activity of Ferulic Acid as an Active Compound, Molecules, 23, 7, 2018. Crossref

  2. El-Agamy Sara Emad, Abdel-Aziz Amal Kamal, Esmat Ahmed, Azab Samar S., Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain, Cancer Chemotherapy and Pharmacology, 84, 1, 2019. Crossref

  3. Farruggia Michael C., Small Dana M., Effects of adiposity and metabolic dysfunction on cognition: A review, Physiology & Behavior, 208, 2019. Crossref

  4. Fernandez Harvey R., Varma Ashima, Flowers Sarah A., Rebeck George William, Cancer Chemotherapy Related Cognitive Impairment and the Impact of the Alzheimer’s Disease Risk Factor APOE, Cancers, 12, 12, 2020. Crossref

  5. Huang Qian , Liu Chan , Li Jia‑Rui , Zhang Ling , Huang Fu‑Chang , Wang Dan , Luo Ya‑Jing , Incremental effect of liraglutide on traditional insulin injections in rats with type 2 diabetes mellitus by maintaining glycolipid metabolism and cardiovascular function, Experimental and Therapeutic Medicine, 2019. Crossref

  6. Onzi Giovana R., D’Agustini Nathalia, Garcia Solange C., Guterres Silvia S., Pohlmann Paula R., Rosa Daniela D., Pohlmann Adriana R., Chemobrain in Breast Cancer: Mechanisms, Clinical Manifestations, and Potential Interventions, Drug Safety, 45, 6, 2022. Crossref

  7. Jordá Adrián, Aldasoro Martin, Campo-Palacio Ignacio, Vila Jose, Aldasoro Constanza, Campos-Campos Juan, Colmena Carlos, Singh Sandeep, Obrador Elena, Valles Soraya, Facilitation of Insulin Effects by Ranolazine in Astrocytes in Primary Culture, International Journal of Molecular Sciences, 23, 19, 2022. Crossref

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