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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2017019457
pages 113-119

Nephrotoxicity in Rats Exposed to Paracetamol: The Protective Role of Moralbosteroid, a Steroidal Glycoside

Gaurav Gupta
School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India
Dinesh Kumar Chellappan
Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia 57000
Irene Satiko Kikuchi
University of São Paulo, Department of Pharmacy, Faculty of Pharmaceutical Sciences, São Paulo, Rua Professor Lineu Prestes 05508-000, Cidade Universitaria, Brazil
Terezinha de Jesus Andreoli Pinto
Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Rua Professor Lineu Prestes, 05508–000, Brazil
Kavita Pabreja
University of Newcastle, School of Medicine and Public Health, Newcastle, NSW 2308, Australia
Mohit Agrawal
School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, Rajasthan, India
Yogendra Singh
Jaipur National University, School of Pharmaceutical Sciences, Jagatpura, 302017, Jaipur, India
Juhi Tiwari
School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, India
Kamal Dua
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW 2007, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Australia and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW 2305, Australia

ABSTRACT

Paracetamol (PCM) has an acceptable safety profile when used at prescribed doses. However, it is now understood that paracetamol can damage the kidneys when administered as an overdose. In addition, oxidative stress can play a major role in causing nephrotoxicity. This investigation studies the efficacy of moralbosteroid isolated from M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential.


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