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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

In Vitro Effects of Phthalate Mixtures on Colorectal Adenocarcinoma Cell Lines

Volume 34, Issue 2, 2015, pp. 115-123
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013256
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ABSTRACT

Among endocrine-disrupting chemicals, phthalates are an important concern because of their wide-spread exposure in humans and environmental contamination. Even though the use of some phthalates has been restricted for toys, some plastics, and food contact materials, exposure to the mixture of these contaminants at very low concentrations in various matrices are still being reported. In the current research, the effects of the mixture of some phthalates were studied. Di-n-butyl phthalate (DBP), n-butyl benzyl phthalate (BBP), di-2-ethylhexyl phthalate (DEHP), diisononyl phthalate (DiNP), di-n-octyl phthalate (DNOP), and diisodecyl phthalate (DiDP) were tested on two colorectal adenocarcinoma cell lines; DLD-1 and HT29 were studied as described before. Cells were treated with increasing log concentrations (0.33 ppt to 33.33 ppb) of the phthalate mixture; cell viability/proliferation was measured by MTT and staining with neutral red and crystal violet; lactate dehydrogenase (LDH) activity was measured following 24-h exposure. Cell viability/proliferation increased from phthalate treatment at concentrations less than 33.33 ppt. The phthalate mixture induced increases in HT29 proliferation of 10.94% at 33.33 ppt and 60.87% at 3.33 ppt, whereas this proliferation relation at lower concentrations was not found for DLD1 cells. The present study demonstrates preliminary information regarding the low dose induction of proliferation of the cancer cells by phthalate mixtures. Because non-monotonic dose responses are still being debated, further studies are required to re-evaluate the reference doses defined by governments for phthalates.

CITED BY
  1. Nicolopoulou-Stamati Polyxeni, Hens Luc, Sasco Annie J., Cosmetics as endocrine disruptors: are they a health risk?, Reviews in Endocrine and Metabolic Disorders, 16, 4, 2015. Crossref

  2. Wei Ning, Feng Xiaoyan, Xie Zhiqin, Zhang Yanan, Feng Ying, Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NFκB, Toxicology in Vitro, 42, 2017. Crossref

  3. Yurdakök-Dikmen Begüm, Arslan Pınar, Kuzukıran Özgür, Filazi Ayhan, Erkoç Figen, Unio sp. primary cell culture potential in ecotoxicology research, Toxin Reviews, 37, 1, 2018. Crossref

  4. Kuzukiran Ozgur, Yurdakok-Dikmen Begum, Sevin Sedat, Sireli Ufuk Tansel, Iplikcioglu-Cil Guzin, Filazi Ayhan, Determination of selected endocrine disruptors in organic, free-range, and battery-produced hen eggs and risk assessment, Environmental Science and Pollution Research, 25, 35, 2018. Crossref

  5. Chen Hsin-Pao, Lee Yung-Kuo, Huang Shih Yin, Shi Pei-Chun, Hsu Ping-Chi, Chang Chuan-Fa, Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells, Oncotarget, 9, 17, 2018. Crossref

  6. Arslan Pınar, Yurdakok-Dikmen Begum, Ozeren Saniye Cevher, Kuzukiran Ozgur, Filazi Ayhan, In vitro effects of erythromycin and florfenicol on primary cell lines of Unio crassus and Cyprinus carpio, Environmental Science and Pollution Research, 28, 35, 2021. Crossref

  7. Ashraf Asma, Kiran Shumaila, Muzammil Saima, Hayat Sumreen, Ijaz Muhammad Umar, Muzammil Aqsa, Phthalates and Neurological Disorders: From Exposure to Preventive Interventions, in Environmental Contaminants and Neurological Disorders, 2021. Crossref

  8. Cuvillier-Hot Virginie, Gaudron Sylvie Marylène, Massol François, Boidin-Wichlacz Céline, Pennel Timothée, Lesven Ludovic, Net Sopheak, Papot Claire, Ravaux Juliette, Vekemans Xavier, Billon Gabriel, Tasiemski Aurélie, Immune failure reveals vulnerability of populations exposed to pollution in the bioindicator species Hediste diversicolor, Science of The Total Environment, 613-614, 2018. Crossref

  9. Huwait Etimad, Al-Saedi Dalal A., Mirza Zeenat, Anti-Inflammatory Potential of Fucoidan for Atherosclerosis: In Silico and In Vitro Studies in THP-1 Cells, Molecules, 27, 10, 2022. Crossref

  10. Orhan Ersin, Dülger Görkem, Alpay Merve, Öksüz Nilüfer, Dülger Başaran, Synthesis, antimicrobial and antiproliferative activities of new self-assembly benzimidazole-bridged aren ruthenium rectangles in human breast cancer cells, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 102, 1-2, 2022. Crossref

  11. Rodriguez-Santiago Yair, Nava-Castro Karen Elizabeth, Morales-Montor Jorge, Environmental pollution as a risk factor to develop colorectal cancer: The role of endocrine-disrupting chemicals in the inflammatory process as a risk factor to develop colorectal cancer, in Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives, 2021. Crossref

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