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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Dillenia suffruticosa L. Impedes Carbon Tetrachloride−Induced Hepatic Damage by Modulating Oxidative Stress and Inflammatory Markers in Rats

Volume 34, Issue 2, 2015, pp. 133-152
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013306
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ABSTRACT

Dillenia suffruticosa L. (Dilleniaceae) is used in traditional medicine for protection against various diseases. The current study was designed to investigate the bioactive compounds and hepatoprotective potential of methanol leaves extract of D. suffruticosa against carbon tetrachloride (CCl4)-induced hepatic oxidative injury. Sprague Dawley rats were pretreated with methanol extract of D. suffruticosa leaves (200, 300, and 400 mg/kg body weight [bwt]) once daily for 14 days followed by two doses of CCl4 (1.0 mL/kg bwt). After 2 weeks the rats were sacrificed and hepatoprotective analysis was performed. The identified bioactive compounds include phenol (1.39%); benzyl alcohol (2.04%); 2H-pyran-2-one, 4,6-dimethyl (1.19%); phenol, 2,4-bis(1,1-dimethylethyl) (0.83%); dodecanoic acid (0.84%); hexadecanoic acid, methyl ester (2.66%); n-hexadecanoic acid (0.96%); and phytol (2.13%). The administration of D. suffruticosa significantly depleted the elevation of enzymatic levels of alanine transaminase and aspartate transaminase (4% to 59% recovery), reduced the extent of malondialdehyde production (13% to 79% recovery), elevated the level of reduced glutathione (5% to 21% recovery), and increased the activities of antioxidant enzymes (0.43% to 35% recovery). Histopathological analyses by light and electron microscopy revealed that the plant extract protects the liver from the toxic effects of CCl4 and cured lesions such as necrosis and fatty degeneration. It also decreased hepatocyte injuries such as irregular lamellar organization and dilations in endoplasmic reticulum. Immunohistochemical studies indicate the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4-hydroxyl-2-nonenal (HNE)-modified protein adducts. In addition, the overexpression of the inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and prostaglandin E2 (PGE2) are reduced. Hence, we find D. suffruticosa to be a good source of bioactive compounds with hepatoprotective effects against CCl4-induced oxidative damage.

CITED BY
  1. Li Sha, Hong Ming, Tan Hor-Yue, Wang Ning, Feng Yibin, Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases, Oxidative Medicine and Cellular Longevity, 2016, 2016. Crossref

  2. Rahman A, Vasenwala SM, Iqbal M, Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats, Human & Experimental Toxicology, 36, 8, 2017. Crossref

  3. Ahmad Ganaie Hilal, Review of the active principles of medicinal and aromatic plants and their disease fighting properties, in Medicinal and Aromatic Plants, 2021. Crossref

  4. Venmathi Maran Balu Alagar, Iqbal Mohammad, Gangadaran Prakash, Ahn Byeong-Cheol, Rao Pasupuleti Visweswara, Shah Muhammad Dawood, Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms, Molecules, 27, 5, 2022. Crossref

  5. Vun-Sang Senty, Rodrigues Kenneth Francis, Dsouza Urban J. A., Iqbal Mohammad, Suppression of Oxidative Stress and Proinflammatory Cytokines Is a Potential Therapeutic Action of Ficus lepicarpa B. (Moraceae) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats, Molecules, 27, 8, 2022. Crossref

  6. Liu Si-Ying, Rao Jian-Xu, Deng Jie, Zhang Gui-Juan, Jiang Xiao-Ling, Cheng Jing, Chen Huan, Jiang Zhi-Gang, Xu De-Lin, He Yi-Huai, Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis, Scientific Reports, 12, 1, 2022. Crossref

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