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Journal of Environmental Pathology, Toxicology and Oncology

Impact factor: 1.246

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i3.30
pages 185-197

Protective Effects of a By-Product of the Pecan Nut Industry (Carya illinoensis) on the Toxicity Induced by Cyclophosphamide in Rats Carya illinoensis Protects Against Cyclophosphamide- Induced Toxicity

Dalila Benvegnu
Universidade Federal da Fronteira Sul
R.C.S. Barcelos
Programa de pós Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
N. Boufleur
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Patricia Reckziegel
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Camila S. Pase
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
L.G. Muller
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
N.M.B. Martins
Departamento de Patologia, Universidade Federal de Santa Maria, RS, Brazil
C. Vareli
Departamento de Quimica, Universidade Federal de Santa Maria, RS, Brazil
M.E. Burger
Programa de pós Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil

ABSTRACT

This study investigated the antioxidant effects of pecan nut (Carya illinoensis) shell aqueous extract (AE) on toxicity induced by cyclophosphamide (CP) in the heart, kidney, liver, bladder, plasma and erythrocytes of rats. Rats were treated with water or pecan shell AE (5%) ad libitum, replacing drinking water for 37 days up to the end of the experiment. On day 30, half of each group received a single administration of vehicle or CP 200 mg/kg-ip. After 7 days, the organs were removed. Rats treated with CP showed an increase in lipid peroxidation (LP) and decrease in reduced glutathione (GSH) levels in all structures. Catalase (CAT) activity was increased in the heart and decreased in liver and kidney. Besides, CP treatment decreased plasmatic vitamin C (VIT C) levels and induced bladder macroscopical and microscopical damages. In contrast, co-treatment with pecan shell AE prevented the LP development and the GSH depletion in all structures, except in the heart and plasma, respectively. CAT activity in the heart and liver as well as the plasmatic VIT C levels remained unchanged. Finally, AE prevented CP-induced bladder injury. These findings revealed the protective role of pecan shell AE in CP-induced multiple organ toxicity.