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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Fluorescence Monitoring of a Topically Applied Liposomal Temoporfin Formulation and Photodynamic Therapy of Nonpigmented Skin Malignancies

Volume 26, Issue 2, 2007, pp. 117-126
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i2.60
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ABSTRACT

Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (INN: Temoporfin) is a potent photodynamically active substance in clinical use today. Usually, the substance is given systemically and a known drawback with this administration route is a prolonged skin light sensitization. For the first time to our knowledge, a liposomal Temoporfin gel formulation for topical application was studied in connection with photodynamic therapy (PDT) of nonpigmented skin malignancies in humans. Intervals of 4 hr between drug administration and light irradiation were used. Sensitizer distribution within tumor and surrounding normal skin was investigated by means of point monitoring and imaging fluorescence spectroscopy before, during, and after PDT, showing high tumor selectivity. Furthermore, the bleaching of Temoporfin was studied during the PDT procedure by monitoring the fluorescence following excitation by using a therapeutic light. A 30−35% light-induced photometabolization was shown. No pain occurred during or after treatment. It was also observed that the treated area did not show any swollen tissue or reddening, as is often seen in PDT using topical δ-aminolevulinic acid. On controlling the patients one week after treatment, healing progress was observed in several patients and no complications were registered.

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  2. Osiecka Beata, Jurczyszyn Kamil, Symonowicz Krzysztof, Bronowicz Andrzej, Ostasiewicz Paweł, Czapińska Elżbieta, Hotowy Katarzyna, Krzystek-Korpacka Małgorzata, Gębarowska Elżbieta, Iżykowska Ilona, Dzięgiel Piotr, Terlecki Grzegorz, Ziółkowski Piotr, In vitro and in vivo matrix metalloproteinase expression after photodynamic therapy with a liposomal formulation of aminolevulinic acid and its methyl ester, Cellular and Molecular Biology Letters, 15, 4, 2010. Crossref

  3. Haj-Hosseini Neda, Richter Johan, Andersson-Engels Stefan, Wårdell Karin, Optical touch pointer for fluorescence guided glioblastoma resection using 5-aminolevulinic acid, Lasers in Surgery and Medicine, 42, 1, 2010. Crossref

  4. Kachatkou Dzmitry, Sasnouski Siarhei, Zorin Vladimir, Zorina Tatyana, D’Hallewin Marie-Ange, Guillemin Francois, Bezdetnaya Lina, Unusual Photoinduced Response of mTHPC Liposomal Formulation (Foslip), Photochemistry and Photobiology, 85, 3, 2009. Crossref

  5. Senge Mathias O., Brandt Johan C., Temoporfin (Foscan®, 5,10,15,20-Tetra(m-hydroxyphenyl)chlorin)-A Second-generation Photosensitizer†,‡, Photochemistry and Photobiology, 87, 6, 2011. Crossref

  6. Rai Prakash, Mallidi Srivalleesha, Zheng Xiang, Rahmanzadeh Ramtin, Mir Youssef, Elrington Stefan, Khurshid Ahmat, Hasan Tayyaba, Development and applications of photo-triggered theranostic agents, Advanced Drug Delivery Reviews, 62, 11, 2010. Crossref

  7. Dragicevic-Curic Nina, Fahr Alfred, Liposomes in topical photodynamic therapy, Expert Opinion on Drug Delivery, 9, 8, 2012. Crossref

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  11. Allison Ron R., Sibata Claudio H., Photodiagnosis for cutaneous malignancy: A brief clinical and technical review, Photodiagnosis and Photodynamic Therapy, 5, 4, 2008. Crossref

  12. Kejík Z., Kaplánek R., Bříza T., Havlík M., Králová J., Martásek P., Král V., Supramolecular Approach in Photodynamic and Photothermal Therapies, in Comprehensive Supramolecular Chemistry II, 2017. Crossref

  13. Akhtar Naseem, Khan Riaz A., Liposomal systems as viable drug delivery technology for skin cancer sites with an outlook on lipid-based delivery vehicles and diagnostic imaging inputs for skin conditions', Progress in Lipid Research, 64, 2016. Crossref

  14. Alves Frauke, Bode Julia, Cimalla Peter, Hilger Ingrid, Hofmann Martin, Jaedicke Volker, Koch Edmund, Licha Kai, Rademakers Timo, Razansky Daniel, van Zandvoort Marc A. M. J., Optical Imaging, in Small Animal Imaging, 2017. Crossref

  15. Wong T.H., Morton C.A., Collier N., Haylett A., Ibbotson S., McKenna K.E., Mallipeddi R., Moseley H., Seukeran D.C., Rhodes L.E., Ward K.A., Mohd Mustapa M.F., Exton L.S., McHenry P.M., Leslie T.A., Wakelin S., Hunasehally R.Y.P., Cork M., Johnston G.A., Worsnop F.S., Rakvit P., Salim A., McDonald B., Chua S.L., Buckley D., Petrof G., Callachand N., Flavell T., Salad A.A., British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018, British Journal of Dermatology, 180, 4, 2019. Crossref

  16. Torchilin Vladimir, Liposomes in Drug Delivery, in Fundamentals and Applications of Controlled Release Drug Delivery, 2012. Crossref

  17. Bombelli Cecilia, Stringaro Annarita, Borocci Stefano, Bozzuto Giuseppina, Colone Marisa, Giansanti Luisa, Sgambato Rosa, Toccaceli Laura, Mancini Giovanna, Molinari Agnese, Efficiency of Liposomes in the Delivery of a Photosensitizer Controlled by the Stereochemistry of a Gemini Surfactant Component, Molecular Pharmaceutics, 7, 1, 2010. Crossref

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  19. González-Delgado José A., Kennedy Patrick J., Ferreira Marta, Tomé João P. C., Sarmento Bruno, Use of Photosensitizers in Semisolid Formulations for Microbial Photodynamic Inactivation, Journal of Medicinal Chemistry, 59, 10, 2016. Crossref

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