Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
Indexed in
Naringenin Alleviates Cadmium-Induced Toxicity through the Abrogation of Oxidative Stress in Swiss Albino Mice
ABSTRACT
The present study evaluates the protective potential of the flavonoid naringenin (NRG) against experimentally induced cadmium (Cd) toxicity in Swiss albino mice. NRG (4 and 8 mg/kg) was orally administered to mice 30 min before oral administration of CdCl2 (12 mg/kg) for 11 consecutive days. On the 12th day, we evaluated body and organ weights, hematological profiles, serum biochemical profiles, and hepatic and renal tissue antioxidative parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, and catalase. Cotreatment with NRG markedly and significantly normalized body and organ weights, hematological profiles, and serum biochemical profiles and significantly modulated all of the hepatic and renal tissue biochemical parameters in Cd-intoxicated mice. The present findings show that NRG possesses a remarkable alleviative effect against Cd-induced toxicity in albino mice, mediated by abrogation of Cd-induced oxidative stress by multiple mechanisms.
-
Priya Lohanathan Bharathi, Baskaran Rathinasamy, Elangovan Pitchai, Dhivya Velumani, Huang Chih-Yang, Padma Viswanadha Vijaya, Tinospora cordifolia extract attenuates cadmium-induced biochemical and histological alterations in the heart of male Wistar rats, Biomedicine & Pharmacotherapy, 87, 2017. Crossref
-
Bhattacharya Sanjib, The role of medicinal plants and natural products in melioration of cadmium toxicity, Oriental Pharmacy and Experimental Medicine, 18, 3, 2018. Crossref
-
Hernández-Aquino Erika, Muriel Pablo, Beneficial effects of naringenin in liver diseases: Molecular mechanisms, World Journal of Gastroenterology, 24, 16, 2018. Crossref
-
Athmouni Khaled, Belhaj Dalel, Chawech Rachid, Jarraya Raoudha, El Feki Abdelfattah, Ayadi Habib, Characterization of polysaccharides isolated from Periploca angustifolia and its antioxidant activity and renoprotective potential against cadmium induced toxicity in HEK293 cells and rat kidney, International Journal of Biological Macromolecules, 125, 2019. Crossref
-
Karim Naymul, Jia Zhenquan, Zheng Xiaodong, Cui Sunliang, Chen Wei, A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production, Trends in Food Science & Technology, 79, 2018. Crossref
-
Jin Yuzi, Wang Hua, Naringenin Inhibit the Hydrogen Peroxide-Induced SH-SY5Y Cells Injury Through Nrf2/HO-1 Pathway, Neurotoxicity Research, 36, 4, 2019. Crossref
-
El-Saad Ahmed Mokhtar Abu, Abdel-Waha Wessam Mohamad, Naringenin Attenuates Toxicity and Oxidative Stress Induced by Lambda-cyhalothrin in Liver of Male Rats, Pakistan Journal of Biological Sciences, 23, 4, 2020. Crossref
-
Bhattacharya Sanjib, The Role of Probiotics in the Amelioration of Cadmium Toxicity, Biological Trace Element Research, 197, 2, 2020. Crossref
-
Chen Cong, Jie Xu, Ou Yangjie, Cao Yini, Xu Lu, Wang Yunxia, Qi Rong, Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice, Nanomedicine, 12, 15, 2017. Crossref
-
Yang Yuanying, Wei Shanshan, Zhang Bikui, Li Wenqun, Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products, Frontiers in Pharmacology, 12, 2021. Crossref
-
Naraki Karim, Rezaee Ramin, Karimi Gholamreza, A review on the protective effects of naringenin against natural and chemical toxic agents, Phytotherapy Research, 35, 8, 2021. Crossref
-
Rajasekar Mani, Adverse effect of synthesized Naringenin derivatives investigate with Zebrafish (Danio rerio) embryos, Results in Chemistry, 2, 2020. Crossref
-
Picos-Salas Manuel Adrian, Cabanillas-Bojórquez Luis Ángel, Elizalde-Romero Cristina Alicia, Leyva-López Nayely, Montoya-Inzunza Luis Aurelio, Heredia J. Basilio, Gutiérrez-Grijalva Erick P., Naringenin as a Natural Agent Against Oxidative Stress and Inflammation, and Its Bioavailability, Food Reviews International, 2022. Crossref