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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i1.50
3 pages

Studies on Sister Chromatid Exchanges in Peripheral Lymphocytes of Spray Painters

Palanivel Gajalakshmi
Department of Genetics, Dr. ALMPGIBMS, University of Madras, Taramani Chennai, India
Protima Mallick
Department of Genetics, Dr. ALMPGIBMS, University of Madras, Taramani Chennai, India
Perumal Venkatesan
Department of Statistics, Tuberculosis Research Centre, ICMR, Chetpet, Chennai, India
Sathyaveedu Thiagarjan Santhiya
Department of Genetics, Dr. ALMPGIBMS, University of Madras, Taramani Chennai, India
Arabandi Ramesh
Department of Genetics, Dr. A. L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Chennai 600 113, India

ABSTRACT

In a comparative study of sister chromatic! exchanges (SCEs) in cultured lym-phocytes, we evaluated the genotoxic risk in 104 male spray painters employed in repair workshops in Chennai City, India, and 50 matched healthy, unexposed controls. We found a higher frequency of SCEs among painters (3.74 ± 0.11, X ± SE) than among controls (2.15 ± 0.08), and among smoking painters (4.03 ± 0.21) than among nonsmoking painters (3.55 ±0.13), with no significant difference in controls (smokers: 2.1 ± 0.2; nonsmokers: 2.2 ± 0.1). Alcoholism did not contribute to an increased SCE frequency. Stepwise multiple linear regression analysis on painters showed that duration of service, smoking, and alcoholism significantly affected SCE scores and explained the 14% variation observed.


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