DNA Single Strand Breaks Induced by Low Levels of Occupational Exposure to Styrene: The Gap between Standards and Reality

Magdy Y. Shamy; Hazem H. Osman; Kamal M. Kandeel; Nehad M. Abdel-Moneim; Khalid F. El Said

doi:10.1615/JEnvironPatholToxicolOncol.v21.i1.40

Journal of Environmental Pathology, Toxicology and Oncology

Editor-in-Chief: Qian Peng (open in a new tab)

Emeritus Editor: Edgar M. Moran (open in a new tab)

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

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DNA Single Strand Breaks Induced by Low Levels of Occupational Exposure to Styrene: The Gap between Standards and Reality

Volume 21, Issue 1, 2002, 5 pages

DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i1.40

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Magdy Y. Shamy
High Institute of Public Health, Occupational Health Department, Alexandria University, Alexandria, Egypt

Hazem H. Osman
Faculty of Sciences, Biochemistry Department, Alexandria University, Alexandria, Egypt

Kamal M. Kandeel
Faculty of Sciences, Biochemistry Department, Alexandria University, Alexandria, Egypt

Nehad M. Abdel-Moneim
Faculty of Sciences, Biochemistry Department, Alexandria University, Alexandria, Egypt

Khalid F. El Said
High Institute of Public Health, Occupational Health Department, Alexandria University, Alexandria, Egypt

ABSTRACT

Styrene is a known mutagen and suspected carcinogen, used in the reinforced plastic industry. This study aims to identify the occurrence of DNA single strand breaks (SSBs) in workers exposed to styrene levels far below the recommended standards. We compared 26 exposed workers with 26 control subjects and found a significant increase in the incidence of DNA-SSBs in the exposed individuals. The levels of the biological indices of exposure (urinary mandelic and phenyl glyoxylic acids) were less than 25% of the recommended limits. Reduction of the threshold limit values/time-weighted-average (TLV-TWA) applied is strongly recommended.

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