Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2014009998
pages 33-43

Gracilaria bursa-pastoris (Gmelin) Silva Extract Attenuates Ultraviolet B Radiation−Induced Oxidative Stress in Human Keratinocytes

Mei Jing Piao
School of Medicine, Jeju National University, Jeju, Republic of Korea
K.C. Kim
School of Medicine, Jeju National University, Jeju, Republic of Korea
J. Zheng
School of Medicine, Jeju National University, Jeju, Republic of Korea
C.W. Yao
School of Medicine, Jeju National University, Jeju, Republic of Korea
J.W. Cha
School of Medicine, Jeju National University, Jeju, Republic of Korea
H.K. Kang
School of Medicine, Jeju National University, Jeju, Republic of Korea
E.S. Yoo
School of Medicine, Jeju National University, Jeju, Republic of Korea
Y.S. Koh
School of Medicine, Jeju National University, Jeju, Republic of Korea
Mi Hee Ko
Jeju Biodiversity Research Institute, Jeju Technopark, Jeju, Republic of Korea
N.H. Lee
Department of Chemistry, College of Natural Sciences, Jeju National University, Jeju, Republic of Korea
Jin Won Hyuna
School of Medicine, Jeju National University, Jeju, Republic of Korea

ABSTRACT

The purpose of this study was to assess the protective effects of an ethanol extract derived from the red alga Gracilaria bursa-pastoris (Gmelin) Silva (GBE) on ultraviolet B (UVB)−irradiated human HaCaT keratinocytes. GBE exhibited scavenging activity against intracellular reactive oxygen species that were induced by either hydrogen peroxide or UVB radiation. In addition, both the superoxide anion and the hydroxyl radical were scavenged by GBE in cell-free systems. GBE absorbed light in the UVB range (280−320 nm) of the electromagnetic spectrum and lessened the extent of UVB-induced oxidative damage to cellular lipids, proteins, and DNA. Finally, GBE-treated keratinocytes showed a reduction in UVB-induced apoptosis, as exemplified by fewer apoptotic bodies. These results suggest that GBE exerts cytoprotective actions against UVB-stimulated oxidative stress by scavenging ROS and absorbing UVB rays, thereby attenuating injury to cellular constituents and preventing cell death.


Articles with similar content:

Black Tea Extract: A Supplementary Antioxidant in Radiation-Induced Damage to DNA and Normal Lymphocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
Salil C. Datta , Subrata Kumar Dey, Sandip Pal, Amit Kumar Chakrabarti, Debjani Ghosh, Chabita Saha
Photoprotective Effect of Carpomitra costata Extract against Ultraviolet B-Induced Oxidative Damage in Human Keratinocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 1
J. C. Lee, N.H. Lee, H.K. Kang, C. S. Ko, Kyoung Ah Kang, Mi Hee Ko, S.R.K. Madduma Hewage, E.S. Yoo, J. Zheng, X Han, Jin Won Hyuna, Mei Jing Piao, Y.S. Koh
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Role of Aqueous Extract of the Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), in Avoidance of Haloperidol-lnduced Catalepsy via Oxidative Stress in Rats
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 4
Gaurav Gupta, Rakesh Kumar Sharma, Xiaohong Liu, Mahaveer Singh, Gopala Krishna Chinnaboina, Anurag Mishra
Amelioration of Sodium Arsenite-Induced Clastogenicity by Tea Extracts in Chinese Hamster V79 Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 2
Maqsood Siddiqi, Madhumita Roy, Rathindra Kumar Bhattacharya, Dona Sinha