Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
Indexed in
Protective Effect of Acacia ferruginea against Ulcerative Colitis via Modulating Inflammatory Mediators, Cytokine Profile and NF-κB Signal Transduction Pathways
ABSTRACT
In the present study, we evaluated the protective effect of A. ferruginea extract against ulcerative colitis (UC). Male Wistar rats received A. ferruginea extract (10 mg/kg body weight) or sulfasalazine (100 mg/kg body weight) for 5 consecutive days before inducing UC via intrarectal acetic acid (3%) administration. Colonic mucosal injury was assessed by macroscopic scoring, vascular permeability testing, and histopathological examination. The mucosal contents of glutathione, lipid peroxidation, superoxide dismutase, and nitric oxide were evaluated as parameters for the redox state. Inflammatory response was determined by measuring inducible nitric oxide synthase (iNOS) and cyclo-oxygenase (COX-2) expression. Myeloperoxidase (MPO), lactate dehydrogenase assay (LDH), tumor necrosis factor (TNF-α), and interleukins (IL-1β and IL-6) were measured using ELISA. Transcription factor profiling of nuclear factor (NF)-κB subunits (p65/p50) was also conducted using ELISA. All of the relevant parameters were altered in rats with UC, and these parameters improved in animals that received A. ferruginea extract. Colonic mucosal injury parallels antioxidant and anti-inflammatory evaluations, and A. ferruginea extract was considered comparable to the standard treatment drug sulfasalazine. Histopathological studies confirmed these findings. A. ferruginea extract inhibited the activation and translocation of transcription factors, that is, NF-κB subunits (p65/p50). The results of our investigation clearly indicate that treatment with A. ferruginea extract exerted a marked protective effect against experimental UC via modulation of oxidant/anti-oxidant balance and inhibition of inflammatory mediators.
-
Soubh Ayman A., Abdallah Dalaal M., El-Abhar Hanan S., Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways, Life Sciences, 136, 2015. Crossref
-
Malago Joshua J., Sangu Catherine L., Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats, Journal of Zhejiang University-SCIENCE B, 16, 3, 2015. Crossref
-
Moura Fabiana Andréa, de Andrade Kívia Queiroz, dos Santos Juliana Célia Farias, Araújo Orlando Roberto Pimentel, Goulart Marília Oliveira Fonseca, Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?, Redox Biology, 6, 2015. Crossref
-
Mohammadi Erfan, Qujeq Durdi, Taheri Hassan, Hajian-Tilaki Karimollah, Evaluation of Serum Trace Element Levels and Superoxide Dismutase Activity in Patients with Inflammatory Bowel Disease: Translating Basic Research into Clinical Application, Biological Trace Element Research, 177, 2, 2017. Crossref
-
Yadav Vipul, Varum Felipe, Bravo Roberto, Furrer Esther, Bojic Daniela, Basit Abdul W., Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets, Translational Research, 176, 2016. Crossref
-
Liu Baohai, Piao Xuehua, Guo Lianyi, Wang Guijun, Sun Weihua, Gao Leming, Zheng Xuefeng, Fang Yanli, A New Chinese Medicine Intestine Formula Greatly Improves the Effect of Aminosalicylate on Ulcerative Colitis, Evidence-Based Complementary and Alternative Medicine, 2017, 2017. Crossref
-
LIU BAOHAI, PIAO XUEHUA, GUO LIANYI, LIU SHANSHAN, CHAI FANG, GAO LEMING, Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice, Molecular Medicine Reports, 13, 6, 2016. Crossref
-
Tian Tian, Wang Ziling, Zhang Jinhua, Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies, Oxidative Medicine and Cellular Longevity, 2017, 2017. Crossref
-
Ali Azza Abdelfattah, Abd Al Haleem Ekram Nemr, Khaleel Sahar Abdel-Hafeez, Sallam Amany Said, Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats, Pharmacological Reports, 69, 2, 2017. Crossref
-
Suluvoy Jagadish Kumar, Sakthivel K.M., Guruvayoorappan C., Berlin Grace V.M., Protective effect of Averrhoa bilimbi L. fruit extract on ulcerative colitis in wistar rats via regulation of inflammatory mediators and cytokines, Biomedicine & Pharmacotherapy, 91, 2017. Crossref
-
Guan Guiping, Lan Shile, Implications of Antioxidant Systems in Inflammatory Bowel Disease, BioMed Research International, 2018, 2018. Crossref
-
Wang Zheng, Wu Xue, Wang Cui-Ling, Wang Li, Sun Chen, Zhang Dong-Bo, Liu Jian-Li, Liang Yan-Ni, Tang Dong-Xin, Tang Zhi-Shu, Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-α/NF-κB and IL-6/STAT3 Pathways, Molecules, 23, 5, 2018. Crossref
-
Zhao Zhenjiang, Jin Guoguo, Ge Yinghui, Guo Zhiping, Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways, Inflammopharmacology, 27, 5, 2019. Crossref
-
Zengin Gokhan, Ferrante Claudio, Menghini Luigi, Orlando Giustino, Brunetti Luigi, Recinella Lucia, Chiavaroli Annalisa, Leone Sheila, Ronci Maurizio, Aumeeruddy Muhammad Zakariyyah, Mahomoodally Mohamad Fawzi, Protective effects of Cotoneaster integerrimus on in vitro and ex-vivo models of H2 O2 -induced lactate dehydrogenase activity in HCT116 cell and on lipopolysaccharide-induced inflammation in rat colon, Journal of Food Biochemistry, 43, 3, 2019. Crossref
-
Wang Zheng, Liang Yanni, Yu Jingao, Zhang Dongbo, Ren Langlang, Zhang Zhen, Liu Yanru, Wu Xue, Liu Li, Tang Zhishu, Guchang Zhixie Wan protects mice against dextran sulfate sodium-induced colitis through modulating the gut microbiota in colon, Journal of Ethnopharmacology, 260, 2020. Crossref
-
Lu Peng-De, Zhao Yong-Hua, Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines, Chinese Medicine, 15, 1, 2020. Crossref
-
Zhang Wei, Chao Xu, Wu Jie‐Qiong, Ma Xiao‐Bing, Yang Yin‐Li, Wu Yang, Lin Jun‐Chao, Exploring the Potential Mechanism of Guchang Zhixie Wan for Treating Ulcerative Colitis by Comprehensive Network Pharmacological Approaches and Molecular Docking Validation as Well as Cell Experiments, Chemistry & Biodiversity, 18, 1, 2021. Crossref
-
Tak Lee-Jung, Kim Hae-Young, Ham Won-Kook, Agrahari Gaurav, Seo Yoojin, Yang Ji Won, An Eun-Joo, Bang Chul Hwan, Lee Min Jung, Kim Hyung-Sik, Kim Tae-Yoon, Superoxide Dismutase 3-Transduced Mesenchymal Stem Cells Preserve Epithelial Tight Junction Barrier in Murine Colitis and Attenuate Inflammatory Damage in Epithelial Organoids, International Journal of Molecular Sciences, 22, 12, 2021. Crossref
-
Saha Manas Ranjan, Dey Priyankar, Pharmacological benefits of Acacia against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota, Archives of Physiology and Biochemistry, 2021. Crossref
-
Yin Qi, Pi Xuelei, Jiang Yuanyuan, Ren Guiping, Liu Zhihang, Liu Han, Wang Mengxia, Sun Wenying, Li Siyu, Gao Zhenqiu, Li Deshan, Yin Jiechao, An immuno-blocking agent targeting IL-1β and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice, Inflammation, 44, 5, 2021. Crossref
-
Liu Gaodan, Feng Simin, Sun Yuxin, Wang Dan, Shao Ping, Sun Peilong, Colonic macrophage-targeted curcumin nanoparticles alleviate DSS-induced colitis in mice through the NF-kappa B pathway, Food Bioscience, 41, 2021. Crossref
-
Morsy Mohamed A., Khalaf Hanaa M., Rifaai Rehab A., Bayoumi Asmaa M.A., Khalifa Esraa M.M.A., Ibrahim Yasmine F., Canagliflozin, an SGLT-2 inhibitor, ameliorates acetic acid-induced colitis in rats through targeting glucose metabolism and inhibiting NOX2, Biomedicine & Pharmacotherapy, 141, 2021. Crossref
-
Jhundoo Henusha D., Siefen Tobias, Liang Alfred, Schmidt Christoph, Lokhnauth John, Moulari Brice, Béduneau Arnaud, Pellequer Yann, Larsen Crilles Casper, Lamprecht Alf, Anti-inflammatory effects of acacia and guar gum in 5-amino salicylic acid formulations in experimental colitis, International Journal of Pharmaceutics: X, 3, 2021. Crossref
-
Jeevitha M., Sripathi Shubashini K., A systematic documentation on a rare medicinal plant Acacia ferruginea: a ready reckoner, Advances in Traditional Medicine, 2022. Crossref
-
Ji Kai-Long, Wu Meng-Zhen, Huang Chao-Ying, GongPan Pian-Chou, Sun Peng, Sun Yi-Li, Li Jia, Xiao Chun-Fen, Xu You-Kai, Fan Qing-Fei, Hu Hua-Bin, Song Qi-Shi, Alpinia hainanensis Rhizome Extract Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis: Active Ingredient Investigation and Evaluation, Journal of Agricultural and Food Chemistry, 70, 13, 2022. Crossref
-
Zheng Shihao, Xue Tianyu, Wang Bin, Guo Haolin, Liu Qiquan, Chinese Medicine in the Treatment of Ulcerative Colitis: The Mechanisms of Signaling Pathway Regulations, The American Journal of Chinese Medicine, 50, 07, 2022. Crossref