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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Inhibitory Effect(s) of Polymeric Black Tea Polyphenols on the Formation of B(a)P-Derived DNA Adducts in Mouse Skin

Volume 24, Issue 2, 2005, pp. 79-90
DOI: 10.1615/JEnvPathToxOncol.v24.i2.20
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Rajesh Krishnan
Tobacco Carcinogenesis Group, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
Girish Maru
Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai-410210, India

ABSTRACT

The biological activities and chemopreventive properties of green tea polyphenols have been demonstrated, while similar information regarding newly formed major polymeric polyphenols in black tea are not available. Cancer chemoprevention may be achieved by the inhibition of any stage of carcinogenesis. In the present study, we investigated the anti-initiating effects of five polymeric black tea polyphenol (PBP) fractions, by determining their effects on the formation of [3H]-B(a)P-derived DNA adducts as well as the activity of cytochrome P-450 isozymes CYP 1A1 and 1A2 in vitro employing rat liver microsomes. PBP 1-3 inhibited both the microsome catalyzed [3H]-B(a)P-derived DNA adduct formation as well as the activity of CYP 1A1 and 1A2 as assessed by the decreased formation of resorufin from the respective substrates. Further investigation revealed that topical pretreatment(s) of mice with PBP 1-5 (200 μg/day × 4) resulted in a significant decrease in the levels of single topical B(a)P (1 mg/mouse) - induced DNA adducts in epidermal DNA determined by employing 32P-post labeling analysis. Overall, our results suggest that black tea-derived PBPs have one of the chemopreventive properties shown by monomeric green tea polyphenols.

CITED BY

  1. Melchini Antonietta, Catania Stefania, Stancanelli Rossana, Tommasini Silvana, Costa Chiara, Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin, Cell Biology and Toxicology, 27, 5, 2011. Crossref

  2. Bassi Daniel E., Klein‐Szanto A.J.P., Carcinogen‐Induced Animal Models of Head and Neck Squamous Cell Carcinoma, Current Protocols in Pharmacology, 37, 1, 2007. Crossref

  3. Patel Rachana, Maru Girish, Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs, Free Radical Biology and Medicine, 44, 11, 2008. Crossref

  4. Ramchandani Asha G., Chettiyar Raghunathan S., Pakhale Shrirang S., Evaluation of antioxidant and anti-initiating activities of crude polyphenolic extracts from seedless and seeded Indian grapes, Food Chemistry, 119, 1, 2010. Crossref

  5. Singletary Keith W., Jung Kwan-Jae, Giusti Monica, Anthocyanin-Rich Grape Extract Blocks Breast Cell DNA Damage, Journal of Medicinal Food, 10, 2, 2007. Crossref

  6. Nagini Siddavaram, Senthil Murugan Ramalingam, Cancer Chemoprevention by Black Tea Polyphenols, in Tea in Health and Disease Prevention, 2013. Crossref

  7. TABREZ SHAMS, PRIYADARSHINI MEDHA, UROOJ MARYAM, SHAKIL SHAZI, ASHRAF GHULAM Md, KHAN MOHD SHAHNAWAZ, KAMAL MOHAMMAD AMJAD, ALAM QAMRE, JABIR NASIMUDEEN R., ABUZENADAH ADEL MOHAMMAD, CHAUDHARY ADEEL G. A., DAMANHOURI GHAZI ABDULLAH, Cancer Chemoprevention by Polyphenols and Their Potential Application as Nanomedicine, Journal of Environmental Science and Health, Part C, 31, 1, 2013. Crossref

  8. Patel R., Krishnan R., Ramchandani A., Maru G., Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation, Cell Proliferation, 41, 3, 2008. Crossref

  9. Hudlikar Rasika R., Venkadakrishnan Varadha Balaji, Kumar Rajiv, Thorat Rahul A., Kannan Sadhana, Ingle Arvind D., Desai Saral, Maru Girish B., Mahimkar Manoj B., Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice, Molecular Carcinogenesis, 56, 2, 2017. Crossref

  10. Murugan Ramalingam Senthil, Uchida Koji, Hara Yukihiko, Nagini Siddavaram, Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model, Free Radical Research, 42, 10, 2008. Crossref

  11. Munnia Armelle, Giese Roger W., Polvani Simone, Galli Andrea, Cellai Filippo, Peluso Marco E.M., , 81, 2017. Crossref

  12. Hudlikar Rasika R., Pai Venkatesh, Kumar Rajiv, Thorat Rahul A., Kannan Sadhana, Ingle Arvind D., Maru Girish B., Mahimkar Manoj B., Dose-Related Modulatory Effects of Polymeric Black Tea Polyphenols (PBPs) on Initiation and Promotion Events in B(a)P and NNK-Induced Lung Carcinogenesis, Nutrition and Cancer, 71, 3, 2019. Crossref

  13. Patel Rachana, Garg Rachana, Erande Suvarna, Maru Girish B., Chemopreventive Herbal Anti-Oxidants: Current Status and Future Perspectives, Journal of Clinical Biochemistry and Nutrition, 40, 2, 2007. Crossref

  14. Peluso Marco, Munnia Armelle, Russo Valentina, Galli Andrea, Pala Valeria, Schouw Yvonne T. van der, Schulze Matthias B., Weiderpass Elisabete, Tumino Rosario, Saieva Calogero, Exezarreta Pilar Amiano, Aune Dagfinn, Heath Alicia K., Aglago Elom, Agudo Antonio, Panico Salvatore, Petersen Kristina Elin Nielsen, Tjønneland Anne, Cirera Lluís, Rodriguez-Barranco Miguel, Katzke Verena, Kaaks Rudolf, Ricceri Fulvio, Milani Lorenzo, Vineis Paolo, Sacerdote Carlotta, Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort), Nutrients, 14, 12, 2022. Crossref

  15. Kumar Gaurav, Dange Prerana, Kailaje Vaishali, Vaidya Milind M., Ramchandani Asha G., Maru Girish B., Polymeric black tea polyphenols modulate the localization and activity of 12-O-tetradecanoylphorbol-13-acetate-mediated kinases in mouse skin: Mechanisms of their anti-tumor-promoting action, Free Radical Biology and Medicine, 53, 6, 2012. Crossref

  16. Nimbalkar Vaishnavi K., Gangar Jeet, Shai Saptarsi, Rane Pallavi, Mohanta Subham Kumar, Kannan Sadhana, Ingle Arvind, Mittal Neha, Rane Swapnil, Mahimkar Manoj B., Prevention of carcinogen-induced oral cancers by polymeric black tea polyphenols via modulation of EGFR-Akt-mTOR pathway, Scientific Reports, 12, 1, 2022. Crossref

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