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Journal of Environmental Pathology, Toxicology and Oncology

Impact factor: 1.246

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i1.90
pages 69-79

Antioxidant and Radiation Antagonistic Effect of Saraca indica

Bola Sadashiva Satish Rao
Department of Radiobiology, Manipal Life Sciences Center, Manipal University, Manipal 576 104, Karnataka
Nageshwar Rao
Manipal
P. R. Archana
Division of Radiobiology & Toxicology, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka
P. Gayathri
1Division of Radiobiology & Toxicology, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka
Prerana Shetty
Department of Pharmachemistry, NGSM Institute of Pharmaceutical Sciences, Mangalore, Karnataka

ABSTRACT

The present study was undertaken to investigate the radiation mitigating effect of hydro-alcoholic extract of Saraca indica (SIE) against mice exposed to whole body gamma radiation. Free radical scavenging ability by SIE was demonstrated using hydroxyl, superoxide anion, ABTS•+ and DPPH radicals generated in vitro. A significant increase in the animal survival (dose reduction factor = 1.39), inhibition in the decline of hematological parameters as well as increased number of spleen colony-forming units was observed when SIE was administered prior to radiation. SIE pretreatment increased the levels of glutathione, glutathione S- trans-ferase, catalase and lowered lipid peroxidation. Our findings for the first time demonstrate the protective potential of SIE against radiation induced syndromes with an optimal dose of 400 mg/kg b.wt. The radiation mitigating effect may be attributed to the mechanisms such as free radical scavenging, elevation in antioxidant status, and reduction in lipid peroxidation.