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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.625 5-Year IF: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i2.60
pages 143-153

Thyroidal Effects of Di-(2-Ethylhexyl) Phthalate in Rats of Different Selenium Status

Pinar Erkekoglu
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey
Belma Kocer-Gumusel
Department of Toxicology, Faculty of Pharmacy, Lokman Hekim University Ankara, Turkey
Murat Kizilgun
Turkish Health Ministry, Ankara Child Health and Diseases, Hematology Oncology Education and Research Hospital, Ankara, Turkey
Isabelle Hininger-Favier
Laboratory of Fundamental and Applied Bioenergetics (LBFA), Universite Joseph Fourier, Grenoble, France
Walid Rachidi
Laboratoire des Lesions des Acides Nucleiques, SCIB, UMR-E CEA/UJF-Grenoble 1, INAC, Grenoble, France
Anne-Marie Roussel
Laboratory of Fundamental and Applied Bioenergetics (LBFA), Universite Joseph Fourier, Grenoble, France
Alain Favier
Laboratoire des Lesions des Acides Nucleiques, SCIB, UMR-E CEA/UJF-Grenoble 1, INAC, Grenoble, France
Filiz Hincal
Faculty of Pharmacy, Department of Toxicology, Hacettepe University, Ankara, Turkey

ABSTRACT

This study was designed to investigate the effects of di-(2-ethylhexyl) phthalate (DEHP) on thyroid hormone levels and oxidant/antioxidant parameters in the rat and to evaluate the effects of selenium status. Selenium deficiency was produced by feeding 3-week-old Sprague-Dawley rats with <0.05 mg selenium/kg body weight for 5 weeks, and the supplementation group received a diet of 1 mg selenium/kg body weight. DEHP-treated groups received the compound at a dose of 1000 mg/kg by gavage during the last 10 days of the feeding period. Levels of thyroid hormone levels as well as selenoenzyme (glutathione peroxidase 1, thioredoxin reductase), catalase, and superoxide dismutase (SOD) activity and thiobarbituric acid reactive substance (TBARS) were measured. Total thyroxine (TT4) levels decreased significantly with DEHP exposure (~25%), whereas TT3 level was not altered. The TT4 lowering effect of DEHP exposure was not affected by selenium deficiency but was observed when animals exposed to DEHP received a selenium supplement. DEHP was found to alter the antioxidant status and induce oxidative stress in rat thyroid by increasing SOD activity (~30%) and TBARS levels (~35%). The effects of DEHP were much more pronounced in selenium-deficient rats, as evidenced by significant increases in SOD activity (~65%) and TBARS levels (~55%) compared with the control levels. Thus, these results show the thyroid-disrupting effect of DEHP in rats and protection by selenium.


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