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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Dosimetry and Radiobiological Studies of Automated Alpha-Particle Irradiator

Volume 32, Issue 3, 2013, pp. 263-273
DOI: 10.1615/JEnvironPatholToxicolOncol.2013009650
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ABSTRACT

Understanding the effect of alpha radiation on biological systems is an important component of radiation risk assessment and associated health consequences. However, due to the short path length of alpha radiation in the atmosphere, in vitro radiobiological experiments cannot be performed with accuracy in terms of dose and specified exposure time. The present paper describes the design and dosimetry of an automated alpha-particle irradiator named 'BARC BioAlpha', which is suitable for in vitro radiobiological studies. Compared to alpha irradiators developed in other laboratories, BARC BioAlpha has integrated computer-controlled movement of the alpha-particle source, collimator, and electronic shutter. The diaphragm blades of the electronic shutter can control the area (diameter) of irradiation without any additional shielding, which is suitable for radiobiological bystander studies. To avoid irradiation with incorrect parameters, a software interlock is provided to prevent shutter opening, unless the user-specified speed of the source and collimator are achieved. The dosimetry of the alpha irradiator using CR-39 and silicon surface barrier detectors showed that ~4 MeV energy of the alpha particle reached the cells on the irradiation dish. The alpha irradiation was also demonstrated by the evaluation of DNA double-strand breaks in human cells. In conclusion, 'BARC BioAlpha' provides a user-friendly alpha irradiation system for radiobiological experiments with a novel automation mechanism for better accuracy of dose and exposure time.

CITED BY
  1. Lee Ki-Man, Lee Ui-Seob, Kim Eun-Hee, A practical alpha particle irradiator for studying internal alpha particle exposure, Applied Radiation and Isotopes, 115, 2016. Crossref

  2. Lee Kwang-Ho, Shin Ji-Yong, Kim Eun-Hee, Measurement of activity distribution in an Am-241 disc source using peeled-off Gafchromic EBT3 films, Applied Radiation and Isotopes, 135, 2018. Crossref

  3. Nawrocki Tomer, Tritt Thomas C, Neti Prasad V S V, Rosen Alex S, Dondapati Akhil R, Howell Roger W, Design and testing of a microcontroller that enables alpha particle irradiators to deliver complex dose rate patterns, Physics in Medicine & Biology, 63, 24, 2018. Crossref

  4. Karthik K., Rajan Vasumathy, Pandey Badri N., Sivasubramanian K., Paul Solomon F.D., Venkatachalam P., Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay, International Journal of Radiation Biology, 95, 6, 2019. Crossref

  5. Roobol , Kouwenberg , Denkova , Kanaar , Essers , Large Field Alpha Irradiation Setup for Radiobiological Experiments, Methods and Protocols, 2, 3, 2019. Crossref

  6. Kanagaraj K., Rajan V., Pandey Badri N., Thayalan K., Venkatachalam P., Primary and secondary bystander effect and genomic instability in cells exposed to high and low linear energy transfer radiations, International Journal of Radiation Biology, 95, 12, 2019. Crossref

  7. Kanagaraj Karthik, Rajan Vasumathy, Pandey BadriN, Venkatachalam Perumal, Complexity of chromosomal aberrations and gene expression changes in human blood lymphocytes after exposure to alpha particle radiation, Journal of Radiation and Cancer Research, 11, 4, 2020. Crossref

  8. Stanley Fintan K T, Berger N Daniel, Pearson Dustin D, Danforth John M, Morrison Hali, Johnston James E, Warnock Tyler S, Brenner Darren R, Chan Jennifer A, Pierce Greg, Cobb Jennifer A, Ploquin Nicolas P, Goodarzi Aaron A, A high-throughput alpha particle irradiation system for monitoring DNA damage repair, genome instability and screening in human cell and yeast model systems, Nucleic Acids Research, 48, 19, 2020. Crossref

  9. Rajan Vasumathy, Pandey Badri Narain, Cytoproliferative effect of low dose alpha radiation in human lung cancer cells is associated with connexin 43, caveolin-1, and survivin pathway, International Journal of Radiation Biology, 97, 3, 2021. Crossref

  10. Ismail Asaad H., Sola Runas Y., Fabrication of alpha irradiation technique and study the impact of low alpha particles density on the lymphoblast cells of Leukemia blood samples, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1031, 2022. Crossref

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