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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v23.i4.60
6 pages

Mutagenic Potential of Mancozeb in Salmonella typhimurium

Yogeshwer Shukla
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,Lucknow, India
Pankaj Taneja
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
Annu Arora
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,Lucknow, India
Neeraj Sinha
Division of Toxicology, Central Drug Research Institute, Lucknow, India

ABSTRACT

Mancozeb, a dithiocarbamate fungicide, was examined for its possible mutagenic activity using Salmonella typhimurium tester strains TA97a, TA98, TA100, and TA102. We found that Mancozeb exhibited toxic effects at the dose of 40 μg/plate and higher with all tester strains. Mancozeb showed dose-dependent increases in the number of revertants with and without metabolic activation when it was dissolved in DMSO or acetone with strain TA97a; however, the number of revertants at the highest dose was less than two-fold compared to control values. We postulate that the true mutagenic potential of Mancozeb may be masked by its toxic effect to the tester strain used.


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