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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2019030154
pages 229-238

Assessment of the Therapeutic Effects of Fucoxanthin by Attenuating Inflammation in Ovalbumin-Induced Asthma in an Experimental Animal Model

Xinjun Yang
Department of Pediatrics, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong City, Shaanxi Province, China
Gang Guo
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Minyan Dang
Department of Scientific Research, Innoscience Research SDN BHD, Subang Jaya, 47650, Selangor, Malaysia
Lei Yan
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Xin Kang
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Kunjin Jia
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Hong Ren
Department of Pediatrics, Ninth Hospital of Xi'an, Xi'an, Shaanxi Province, China

ABSTRACT

Asthma has affected more than 300 million people worldwide and is considered one of the most debilitating global public health problems based on a recent statistical report from the Global Initiative for Asthma. Inflammation of the airways leads to the various interrelated mechanisms of innate and adaptive immunity acting mutually with the epithelium of the respiratory organ. Fucoxanthin is an orange or brown pigment which is naturally found in various seaweeds. To the best of our knowledge, there are no scientific claims or evidence of the curative effects of fucoxanthin against asthma. Hence, this present research was designed to investigate the curative activity of fucoxanthin against ovalbumin-induced asthma in a mouse model. Fucoxanthin (50 mg/kg) showed significant (P < 0.001) antiasthma activity. It effectively decreased intracellular secretion of reactive oxygen species and increased antioxidant enzyme activity. Fucoxanthin also decreased inflammatory cytokine markers in bronchoalveolar lavage fluid. Because fucoxanthin showed effective antiasthma activity against ovalbumin-induced asthma in experimental animals, further research on this natural antioxidant could lead to development of a novel drug for the treatment of asthma in humans.

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