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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.60
pages 55-70

Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system

Rashmi Sisodia
University of Rajasthan, Jaipur
Smita Singh
Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan; Biyani Girls College, Jaipur, India
chaturbhuj Mundotiya
University of rajasthan
Ekta Meghnani
Mahatama Gandhi Institutes of Applied Sciences, Jaipur, India
Preeti Srivastava
Department of Zoology, Mahatma Jyoti Rao Phooley University, Jaipur, India

ABSTRACT

Prunus avium (family Rosaceae) has been used ethnomedicinally for the treatment of many diseases, but its radioprotective efficacy has hardly been explored. Presence of high anthocyanin content and phenolic compound with good antioxidative capacity has been reported by researchers. Its radioprotective effect against 5, 7, 10 and 12 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded LD50/30 5.81 and 9.43Gy for irradiated only and PAE + radiation groups, respectively. The Dose Reduction Factor (DRF) was computed as 1.62. For biochemical and hematological studies, Swiss albino mice were divided into four groups: (1) control (vehicle treated); (2) PAE (P. avium fruit extract) treated (450 mg kg/day for 15 consequetive days); (3) irradiated (5 Gy) and (4) PAE + irradiated. The irradiation of animals resulted in a significant elevation of lipid peroxidation and depletion in glutathione and protein levels in blood serum and spleen which could be significantly checked by administration of PAE. Radiation induced deficit in blood sugar, cholesterol and hematological constituents could also be modulated by supplementation of PAE before and after irradiation. The possible prophylactic and therapeutic action noted by P. avium against radiation-induced metabolic disorders may be due to synergistic action of various antioxidants, minerals, vitamins etc. present in the fruit. Further mechanistic studies aimed at identifying the role of major ingredients in the extract are needed.


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