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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo

Volume 30, Issue 1, 2011, pp. 1-10
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.10
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ABSTRACT

The effect of SN-38 was evaluated on multiple lung cancer cell lines. It inhibits anchorage-dependent and -independent growth as monitored by MTT and soft agar colony assay, respectively. SN-38 collapsed the mitochondrial membrane potential (MMP), arrested cells in S- and G2-phases of the cell cycle, and induced apoptosis via activation of caspase 3 and PARP. A single injection of 2mg/kg body weight of SN-38 caused a significant reduction of lung cancer xenografts. These findings indicate that SN-38 induces apoptosis in the lung cancer cells effectively. Thus, SN-38 can potentially be an effective therapeutic agent against lung cancer.

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  5. Zou Jianling, Li Shuang, Chen Zuhua, Lu Zhihao, Gao Jing, Zou Jianyin, Lin Xiaoting, Li Yanyan, Zhang Cheng, Shen Lin, A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo, Cell Death & Disease, 9, 6, 2018. Crossref

  6. Lukina Maria M., Dudenkova Varvara V., Shimolina Lyubov’ E., Snopova Ludmila B., Zagaynova Elena V., Shirmanova Marina V., In vivo metabolic and SHG imaging for monitoring of tumor response to chemotherapy, Cytometry Part A, 95, 1, 2019. Crossref

  7. Bieniek Adam, Terzyk Artur P., Wiśniewski Marek, Roszek Katarzyna, Kowalczyk Piotr, Sarkisov Lev, Keskin Seda, Kaneko Katsumi, MOF materials as therapeutic agents, drug carriers, imaging agents and biosensors in cancer biomedicine: Recent advances and perspectives, Progress in Materials Science, 117, 2021. Crossref

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  10. Sharpe Martyn A., Marcano Daniela C., Berlin Jacob M., Widmayer Marsha A., Baskin David S., Tour James M., Antibody-Targeted Nanovectors for the Treatment of Brain Cancers, ACS Nano, 6, 4, 2012. Crossref

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