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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2014011859
pages 349-361

Antioxidative Effects of Schidandrin B and Green Tea Polyphenols Against Mercuric Chloride-Induced Hepatotoxicity in rats

Yu Deng
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Zhaofa Xu
Department of Environmental Health, School of Public Health, China Medical University
Bin Xu
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Wei Liu
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Shu Feng
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Tianyao Yang
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001

ABSTRACT

In the present study, we investigated the hepatoprotective effects of schisandrin B (Sch B) and green tea polyphenols (GrTP), two natural antioxidants, against Hg hepatotoxicity. Fifty-six rats were randomly divided into four groups of fourteen animals in each group: control group, Hg-treated group, Sch B pretreated group, and GrTP pretreated group. HgCl2 injection increased Hg accumulation, pathological and ultrastructural injury, lactate dehydrogenase (LDH) level, alanine transaminase (ALT) level, apoptosis, reactive oxygen species (ROS) level, glutathione (GSH) level, and malondialdehyde (MDA) level. HgCl2 injection decreased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities. Sch B and GrTP protected against Hg-induced dysfunction and liver injury by enhancing the antioxidant defense system. Our results indicate that Sch B and GrTP exert antioxidative effects against Hg-induced hepatotoxicity in rats.


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