Library Subscription: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Curcumin, a Potential Inhibitor of MMP-2 in Human Laryngeal Squamous Carcinoma Cells HEp2

Volume 25, Issue 4, 2006, pp. 679-690
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i4.70
Get accessGet access

ABSTRACT

Curcumin (diferuloylmethane) has been widely studied for its tumor inhibiting and anticarcino-genic properties. In the present communication, we studied the effect of curcumin on matrix-metalloproteinase-2 (MMP-2), integrin receptors, and focal adhesion kinase (FAK) in human laryngeal cancer cells, HEp2. Methods: HEp2 cells were treated with curcumin (5 μM) for 30 days and then grown without curcumin for 28 days. Effect of curcumin on MMP-2 expression and activity and on membrane type matrixmetalloproteinase-1 (MT1-MMP), FAK, and integrin receptors was studied by zymography, Western blot, ELISA, RT-PCR, and cell adhesion assay. Results: Treatment of HEp2 cells with curcumin downregulated MMP-2 expression and activity and expression of integrin receptors, FAK, and MT1-MMP to almost background levels. MMP-2 (but not MMP-9) mRNA expression was abolished on curcumin treatment, indicating specific inhibition of MMP-2. Invasive potential of HEp2 cells was also significantly reduced. After drug withdrawal, expression of MMP-2, integrin receptors, MT1-MMP, and FAK returned to control levels. However, MMP-2 activity in serum free medium remained low. Conclusions: Downregulation of integrin receptors and low levels of FAK may hinder integrin-mediated signal transduction, preventing upregulation of MMP-2 activity. Reduction of MMP-2 activity and inhibition of HEp2 cell invasion by curcumin strongly indicate the potential of curcumin as an inhibitor of tumor cell invasion and metastasis.

CITED BY
  1. Sahebkar Amirhossein, Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?, BioFactors, 39, 2, 2013. Crossref

  2. Kumar Dileep, Kumar Manish, Saravanan Chinnadurai, Singh Sushil Kumar, Curcumin: a potential candidate for matrix metalloproteinase inhibitors, Expert Opinion on Therapeutic Targets, 16, 10, 2012. Crossref

  3. Herbal approaches to pathological states, in Principles and Practice of Phytotherapy, 2013. Crossref

  4. Goel Ajay, Kunnumakkara Ajaikumar B., Aggarwal Bharat B., Curcumin as “Curecumin”: From kitchen to clinic, Biochemical Pharmacology, 75, 4, 2008. Crossref

  5. Martins Rodrigo Molina, Pereira Simone Vieira, Siqueira Silvia, Salomão Wellington Fioravante, Freitas Luis Alexandre Pedro, Curcuminoid content and antioxidant activity in spray dried microparticles containing turmeric extract, Food Research International, 50, 2, 2013. Crossref

  6. Das Tanya, Sa Gaurisankar, Saha Baisakhi, Das Kaushik, Multifocal signal modulation therapy of cancer: ancient weapon, modern targets, Molecular and Cellular Biochemistry, 336, 1-2, 2010. Crossref

  7. Ilieva Y., Kaloyanov K., Yosifov D., Robev B., Zhelezova I., Genova M., Mihova A., Balatzenko G., Zaharieva M. M., Berger M. R., Konstantinov S. M., Antineoplastic potential of curcumin (cooperative study in Bulgaria and Germany), Phytochemistry Reviews, 13, 2, 2014. Crossref

  8. Sahu R P, Batra S, Srivastava S K, Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells, British Journal of Cancer, 100, 9, 2009. Crossref

  9. Gupta Subash C., Kim Ji Hye, Prasad Sahdeo, Aggarwal Bharat B., Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals, Cancer and Metastasis Reviews, 29, 3, 2010. Crossref

  10. Weng Chia-Jui, Yen Gow-Chin, Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives, Cancer Treatment Reviews, 38, 1, 2012. Crossref

  11. Huang Wu-Yang, Cai Yi-Zhong, Zhang Yanbo, Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention, Nutrition and Cancer, 62, 1, 2009. Crossref

  12. Amin A.R.M. Ruhul, Karpowicz Phillip A., Carey Thomas E., Arbiser Jack, Nahta Rita, Chen Zhuo G., Dong Jin-Tang, Kucuk Omer, Khan Gazala N., Huang Gloria S., Mi Shijun, Lee Ho-Young, Reichrath Joerg, Honoki Kanya, Georgakilas Alexandros G., Amedei Amedeo, Amin Amr, Helferich Bill, Boosani Chandra S., Ciriolo Maria Rosa, Chen Sophie, Mohammed Sulma I., Azmi Asfar S., Keith W. Nicol, Bhakta Dipita, Halicka Dorota, Niccolai Elena, Fujii Hiromasa, Aquilano Katia, Ashraf S. Salman, Nowsheen Somaira, Yang Xujuan, Bilsland Alan, Shin Dong M., Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds, Seminars in Cancer Biology, 35, 2015. Crossref

  13. Pavan Aline, Silva Gabriel, Jornada Daniela, Chiba Diego, Fernandes Guilherme, Man Chin Chung, dos Santos Jean, Unraveling the Anticancer Effect of Curcumin and Resveratrol, Nutrients, 8, 11, 2016. Crossref

  14. Van Hung Pham, Vo Thi Ngoc Duyen, Structure, physicochemical characteristics, and functional properties of starches isolated from yellow (Curcuma longa ) and black (Curcuma caesia ) turmeric rhizomes, Starch - Stärke, 69, 5-6, 2017. Crossref

  15. Shanmugam Muthu, Rane Grishma, Kanchi Madhu, Arfuso Frank, Chinnathambi Arunachalam, Zayed M., Alharbi Sulaiman, Tan Benny, Kumar Alan, Sethi Gautam, The Multifaceted Role of Curcumin in Cancer Prevention and Treatment, Molecules, 20, 2, 2015. Crossref

  16. Javeri Indu, Chand Naresh, Curcumin, in Nutraceuticals, 2016. Crossref

  17. CHEN QIAN, GAO QING, CHEN KUNLUN, WANG YIDONG, CHEN LIJUAN, LI XU, Curcumin suppresses migration and invasion of human endometrial carcinoma cells, Oncology Letters, 10, 3, 2015. Crossref

  18. Fernandes Mirela Garcia, Cervi Camila Bitencourt, Aparecida de Carvalho Rosemary, Lapa-Guimarães Judite, Evaluation of Turmeric Extract as an Antioxidant for Frozen Streaked Prochilod (Prochilodus lineatus) Fillets, Journal of Aquatic Food Product Technology, 26, 9, 2017. Crossref

  19. Aggarwal Bharat B., Van Kuiken Michelle E., Iyer Laxmi H., Harikumar Kuzhuvelil B., Sung Bokyung, Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis, Experimental Biology and Medicine, 234, 8, 2009. Crossref

  20. Tan Cheng, Zhang Li, Cheng Xian, Lin Xiu-Feng, Lu Rong-Rong, Bao Jian-Dong, Yu Hui-Xin, Curcumin inhibits hypoxia-induced migration in K1 papillary thyroid cancer cells, Experimental Biology and Medicine, 240, 7, 2015. Crossref

  21. Schmitt Florian, Subramaniam Dharmalingam, Anant Shrikant, Padhye Subhash, Begemann Gerrit, Schobert Rainer, Biersack Bernhard, Halogenated Bis(methoxybenzylidene)-4-piperidone Curcuminoids with Improved Anticancer Activity, ChemMedChem, 13, 11, 2018. Crossref

  22. Silva Gabriel, Teixeira Lima Felipe, Seba Viviane, Mendes Lourenço Ana, Lucas Thaise, de Andrade Bianca, Torrezan Guilherme, Polaquini Carlos, Garcia Marcelo, Couto Lucélio, Bestetti Reinaldo, de Castro França Suzelei, Fachin Ana, Regasini Luis, Marins Mozart, Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27, Molecules, 23, 2, 2018. Crossref

  23. Bachmeier Beatrice, Killian Peter, Melchart Dieter, The Role of Curcumin in Prevention and Management of Metastatic Disease, International Journal of Molecular Sciences, 19, 6, 2018. Crossref

  24. Calaf Gloria M., Roy Debasish, Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model, International Journal of Oncology, 51, 5, 2017. Crossref

  25. Wan Mohd Tajuddin Wan Nur Baitty, Lajis Nordin H., Abas Faridah, Othman Iekhsan, Naidu Rakesh, Mechanistic Understanding of Curcumin’s Therapeutic Effects in Lung Cancer, Nutrients, 11, 12, 2019. Crossref

  26. Zhang Ruiwen, Nag Subhasree, Nutraceuticals in Preventive Oncology: Chemical Biology and Translational Pharmaceutical Science, in Pharma-Nutrition, 12, 2014. Crossref

  27. Sharma Prachi, Manchanda Ritu, Goswami Rajesh, Chawla Sanjeev, Biodiversity and Therapeutic Potential of Medicinal Plants, in Environmental Concerns and Sustainable Development, 2020. Crossref

  28. Tailor Dhanir, Singh Rana P., Dietary and Non-dietary Phytochemicals in Cancer Control, in Nutrition, Diet and Cancer, 2012. Crossref

  29. Sukati Suriyan, Khobjai Warachate, Total Phenolic Content and DPPH Free Radical Scavenging Activity of Young Turmeric Grown in Southern Thailand, Applied Mechanics and Materials, 886, 2019. Crossref

  30. Golonko A., Lewandowska H., Świsłocka R., Jasińska U.T., Priebe W., Lewandowski W., Curcumin as tyrosine kinase inhibitor in cancer treatment, European Journal of Medicinal Chemistry, 181, 2019. Crossref

  31. Kumaravel Mohankumar, Sankar Pajaniradje, Latha Periyasamy, Benson Chellakan S, Rukkumani Rajagopalan, Antiproliferative Effects of an Analog of Curcumin in Hep-2 cells: A Comparative Study with Curcumin, Natural Product Communications, 8, 2, 2013. Crossref

  32. Desam Nagarjuna Reddy, Al-Rajab Abdul Jabbar, Herbal biomolecules: anticancer agents, in Herbal Biomolecules in Healthcare Applications, 2022. Crossref

  33. Mohankumar Kumaravel, Francis Arul Prakash, Pajaniradje Sankar, Rajagopalan Rukkumani, Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway, Molecular Biology Reports, 48, 8, 2021. Crossref

  34. Wroński Paweł, Wroński Stanisław, Kurant Marcin, Malinowski Bartosz, Wiciński Michał, Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer, Nutrients, 14, 1, 2021. Crossref

  35. Davoodvandi Amirhossein, Farshadi Marjan, Zare Noushid, Akhlagh Seyed Amirreza, Alipour Nosrani Esmail, Mahjoubin-Tehran Maryam, Kangari Parisa, Sharafi Seyedeh Maryam, Khan Haroon, Aschner Michael, Baniebrahimi Ghazaleh, Mirzaei Hamed, Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers, Frontiers in Pharmacology, 12, 2021. Crossref

  36. Sharma Garima, Nim Shalu, Alle Madhusudhan, Husen Azamal, Kim Jin-Chul, Nanoparticle-Mediated Delivery of Flavonoids for Cancer Therapy: Prevention and Treatment, in Smart Nanomaterials in Biomedical Applications, 2021. Crossref

  37. Arip Masita, Yap Vi Lien, Rajagopal Mogana, Selvaraja Malarvili, Dharmendra K, Chinnapan Sasikala, Evidence-Based Management of Uterine Fibroids With Botanical Drugs-A Review, Frontiers in Pharmacology, 13, 2022. Crossref

  38. Mahmoudi Ali, Atkin Stephen L., Jamialahmadi Tannaz, Banach Maciej, Sahebkar Amirhossein, Effect of Curcumin on Attenuation of Liver Cirrhosis via Genes/Proteins and Pathways: A System Pharmacology Study, Nutrients, 14, 20, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain