Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i2.20
7 pages

Bioactive Anthocyanins Detected in Human Urine after Ingestion of Blackcurrant Juice

Michael Netzel
Institute of Nutritional Science, Justus-Liebig-University Giessen, Giessen, Germany; Institute of Nutritional Sciences, Friedrich-Schiller-University Jena, Jena, Germany
Gabriele Strass
Institute of Nutritional Science, Justus-Liebig-University Giessen, Giessen, Germany
Marlies Janssen
Institute of Nutritional Science, Justus-Liebig-University Giessen, Giessen, Germany
Irmgard Bitsch
Institute of Nutritional Science, Justus-Liebig-University Giessen, Giessen, Germany
Roland Bitsch
Institute of Nutritional Sciences, Friedrich-Schiller-University Jena, Jena, Germany

ABSTRACT

Anthocyanins are a group of very efficient bioactive compounds that are widely distributed in plant food. Several fruits (blackcurrant, blackberry, red grape) and some vegetables (eggplant, onion, red radish) are rich sources of these natural pigments. Extracts of some of them are used as food colorants as well as components of pharmaceutical preparations and functional foods. Anthocyanins, through their ability to inhibit radical reactions, are considered to exert several protective effects in the human body. Until now there has been only a small amount of data available on their capability, in intact or metabolized form, to reach the systemic circulation of humans. The present study was designed to determine the potential bioavailability in humans of the most important anthocyanins of blackcurrants: delphinidine-3-glucoside, delphinidine-3-rutinoside, cyanidine-3-glucoside, and cyanidine-3-rutinoside.Urinary samples from 4 healthy volunteers (2 women and 2 men) were collected before (baseline) and over a period of 5 hours with intervals of 30 minutes after the ingestion of 200 mL of blackcurrant juice (containing 153 mg of anthocyanins). Using high-performance liquid chromatography (HPLC), it was possible to quantify the 4 main anthocyanins of blackcurrants, excreted unchanged in the urine (0.020–0.050% of the oral doses). We present data on the bioavailability in humans of blackcurrant anthocyanins, which are dietary antioxidants with possible biological effects.


Articles with similar content:

Evaluation of Antiarthritic Activity of Butanol Fraction of Punica granatum Linn. Rind Extract Against Freund’s Complete Adjuvant-Induced Arthritis in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 1
Komal Sharma, Gaurav Gupta, Sanjay Sharma, Rupesh Kumar Gautam
Medicinal Value of Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilat (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Christopher Hobbs
28-Day Oral Safety Evaluation of Extracellular Polysaccharopeptides Produced in Submerged Culture from the Turkey Tail Medicinal Mushroom Trametes versicolor (L.:Fr.) Pilát LH-1 in Mice
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Fang-Yi Lin, Ju-Fang Teng, Chun-Hong Lai, Po-Wen Yang, Tai-Hao Hsu, Hui-Chen Lo
Assessment of Anti-inflammatory, Lipid Peroxidation and Acute Toxicity of Extracts Obtained From Wild Higher Basidiomycetes Mushrooms Collected From Akure (Southwest Nigeria)
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 6
Antonio Nieto-Camacho, Victor O. Oyetayo, Baldomero Esquivel Rodriguez, Manuel Jimenez
Preclinical Evaluation of Concurrent Medicinal Mushroom-Based Immune-Enhancement Supplementation in Dogs Undergoing Chemotherapy for Various Cancers
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 2
Sharon Y. West, Marie N. Mullins, Matt P. Cleaver, Britt M. Gianotti