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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018028386
pages 51-59

Mitogen-Activated Protein Kinase (MAPK): New Insights in Breast Cancer

Huanyu Lu
Shandong University, Cheeloo College of Medicine, Jinan, Shandong Province, 250012, China
Yue Guo
Shandong University, Cheeloo College of Medicine, Jinan, Shandong Province, 250012, China
Gaurav Gupta
School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India
Xingsong Tian
Shandong University, Cheeloo College of Medicine, Jinan, Shandong Province, 250012, China

ABSTRACT

The eukaryotic cell cycle via mitogen-activated protein kinase (MAPK) has been considered as an effective signaling cascade pathway for anticancer therapy. In addition to the MAPK signaling pathway, the Rat Sarcoma Virus (Ras)/Rapidly Accelerated Fibrosarcoma (Raf)/MAPK–ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is a signaling cascade that has a crucial role to play in cell survival and development of cancer, especially breast cancer. Novel drugs and clinical trials need to be investigated, taking into consideration the already studied genetic defects related to genesis of tumors in certain populations. The present review provides novel insights into current anticancer treatments involving the MAPK pathway.


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