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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018028403
pages 61-68

Common Variants rs3815188 and rs1043994 on Notch3 Gene Confer Susceptibility to Lung Cancer: A Hospital-Based Case–Control Study

Emine Yagci
Eskisehir Osmangazi University, Medical Faculty, Department of Medical Biology, Eskisehir, Turkey
Irfan Degirmenci
Kutahya Health Sciences University, Medical Faculty, Department of Medical Biology, Kutahya, Turkey
Cansu Ozbayer
Kutahya Health Sciences University, Faculty of Health Sciences, Kutahya, Turkey
Guntulu Ak
Eskisehir Osmangazi University, Medical Faculty, Lung and Pleural Cancers Research and Clinical Center, Eskisehir, Turkey
Faruk Saydam
Recep Tayyip Erdogan University, Medical Faculty, Department of Medical Biology and Genetics, Rize, Turkey
Muzaffer Metintas
Eskisehir Osmangazi University, Medical Faculty, Lung and Pleural Cancers Research and Clinical Center, Eskisehir, Turkey

ABSTRACT

The Notch signaling pathway is a mechanism that plays a role in the determination of cell fate during cell development. Signals between neighbor cells are amplified through the Notch receptors. Notch activity is related to general growth stages such as organogenesis and morphogenesis and has effects on cell differentiation, cell proliferation, and apoptosis. Lung cancer associated with degradation of proteins which regulate cellular activities such as cell growth, differentiation, proliferation and apoptosis or the loss of function of proteins due to mutations in the genes which that express these proteins. We aimed to determine the frequency of the Notch3 rs3815188 (C381T) and rs1043994 (G684A) polymorphisms and to investigate whether this gene is associated with genetic predisposition of development of lung cancer. In this study, DNA samples were extracted from the venous blood sample of 200 subjects (100 lung cancer patients and 100 controls). Notch3 rs3815188 (C381T) and rs1043994 (G684A) polymorphisms were determined using the restriction fragment length polymorphism method. A statistically significant difference was found between the patient and control groups for Notch3 gene rs3815188 and rs1043994 polymorphisms when evaluated in terms of genotype (p = 0.002 and p < 0.001, respectively) and allele frequencies (p < 0.05). In conclusion, the rs3815188 variant and rs1043994 variant of the Notch3 gene is associated with lung cancer risk in patients of Turkish origin.


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