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Journal of Environmental Pathology, Toxicology and Oncology

Impact factor: 1.246

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i3.60
5 pages

Increased Pathology Incidence in the Forestomach of Rats Maintained on a Diet Containing Ivermectin and Given a Single Dose of N-Methyl-N1-Nitro-N-Nitrosoguanidine

P. J. O'Connor
Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK
F. MacNaught
Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK
W. H. Butler
Bletchingly, Surrey, School of Epidemiology and Health Sciences, The University of Manchester, Manchester, UK
D. P. Cooper
Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK; Current address: Micromass UK Ltd., Floats Road, Wythenshawe, Manchester
G. P. Margison
Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK
A. C. Povey
Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK

ABSTRACT

Ivermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) bygavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the fore-stomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.