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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.625 5-Year IF: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i4.60
pages 311-323

Evaluation of Evidenced-Based Radioprotective Effi cacy of Gymnema sylvestre Leaves in Mice Brain

K. V. Sharma
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan 302055
Umang Singh
Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085
Sharad Vats
Department of Botany, University of Rajasthan, Jaipur 302055
K. I. Priyadarsini
Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085
A. L. Bhatia
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302055
Raka Kamal
Department of Botany, University of Rajasthan, Jaipur 302055

ABSTRACT

A Gymnema sylvestre leaves extract (GSE) rich in gymnemic acids was examined for its antioxidant activities through various in vitro assays, along with its radioprotective efficacy in mice brain. The IC50 values of GSE for 2,2-diphenyl-1-picrylhydrazyl scavenging assays, superoxide radical scavenging assays, inhibition of in vitro lipid peroxidation assays, and protein carbonyl formation assay were 238, 140, 99.46, and 28.03 μg/mL, respectively. Furthermore, the total phenolic content in GSE was equivalent to 18.06 μg/mL of Gallic acid. The rate of •OH radical scavenging activity of GSE is 0.46 times slower than SCN− derived from nanosecond pulse radiolysis studies. Results of in vivo studies showed that radiation (8 Gy)-induced augmentation in the levels of lipid peroxidation and depletion in glutathione and protein levels in mice brain were significantly ameliorated by GSE pretreatment. Results suggest that the radioprotective effi cacy of GSE may be due to its antioxidant properties.


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