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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018025223
pages 15-25

Noncoding RNAs (ncRNA) in Hepato Cancer: A Review

Xiujuan Sun
Pathology Department, Liuzhou Municipal Liutie Central Hospital, Liuzhou 545007, Guangxi, China
Anshoo Malhotra
Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160047

ABSTRACT

Hepatocellular carcinoma (HCC) has emerged as a prominent cancer in both developing and developed countries. Due to the increasing burden of HCC patients, massive resources are expended in their management. Furthermore, there is an urgent need to identify new molecular players that could be targeted to halt cancer development in the early phases. Noncoding RNAs (ncRNAs), which were previously thought to lack value, have the potential to play a pivotal role in the present era of personalized and translational research. Several recent studies have reported the involvement of ncRNAs in initiating, regulating, and nurturing HCC. This review provides insights regarding recently reports of noncoding RNAs and their diverse roles in initiation and development of hepatocellular carcinoma.


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