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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Combined Administration of Monosodium Glutamate and High Sucrose Diet Accelerates the Induction of Type 2 Diabetes, Vascular Dysfunction, and Memory Impairment in Rats

Volume 37, Issue 1, 2018, pp. 63-80
DOI: 10.1615/JEnvironPatholToxicolOncol.2018017186
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ABSTRACT

In this study, we aimed to develop an experimental animal model for type 2 diabetes mellitus (T2DM) using a combination of monosodium glutamate (MSG) and high sucrose diet (HSD). Young male Wistar rats (20–30 g) were injected with MSG (2 or 4 mg/g, i.p. for 4 days). These rats were also fed an HSD, while the control group was fed a starch diet (SFD) for 150 days. Parameters assessed periodically were body weight, feed intake, blood glucose level, and oral glucose tolerance test (OGTT), lipid profile, liver and kidney function tests, skeletal muscle glucose uptake, cognitive function tests, and microvascular changes using isolated rat aorta. Histological changes in pancreas, liver, and kidney tissue were assessed using hematoxylin and eosin staining, whereas brain tissue was assessed using cresyl violet stain. Feeding MSG in combination with HSD in rats significantly increased body weight, and produced hyperglycemia, dyslipidemia, and hyperinsulinemia. Animals developed frank diabetic complications, which included insulin resistance in skeletal muscle, hypertension, vascular dysfunction, nephropathy, and dementia. Histological studies revealed neuronal loss with necrotic bodies in the brain, reduction in glomerular count in kidney, and severe hypertrophy and hyperplasia in the islets of Langerhans. These results indicate the successful induction of type-2 diabetes along with several diabetic complications by combining MSG with HSD.

CITED BY
  1. Zhang Yin, Zhang Longyi, Venkitasamy Chandrasekar, Pan Zhongli, Ke Huan, Guo Siya, Wu Di, Wu Wanxia, Zhao Liming, Potential effects of umami ingredients on human health: Pros and cons, Critical Reviews in Food Science and Nutrition, 60, 13, 2020. Crossref

  2. Nuthikattu Saivageethi, Milenkovic Dragan, Norman Jennifer E., Rutledge John, Villablanca Amparo, Inhibition of Soluble Epoxide Hydrolase Is Protective against the Multiomic Effects of a High Glycemic Diet on Brain Microvascular Inflammation and Cognitive Dysfunction, Nutrients, 13, 11, 2021. Crossref

  3. Moldovan Octavia-Laura, Rusu Aura, Tanase Corneliu, Vari Camil-Eugen, Glutamate - A multifaceted molecule: Endogenous neurotransmitter, controversial food additive, design compound for anti-cancer drugs. A critical appraisal, Food and Chemical Toxicology, 153, 2021. Crossref

  4. Celestino Michele, Balmaceda Valdez Valeria, Brun Paola, Castagliuolo Ignazio, Mucignat-Caretta Carla, Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice, Scientific Reports, 11, 1, 2021. Crossref

  5. Montera Vanessa dos Santos Pereira, Martins Ana Paula Bortoletto, Borges Camila Aparecida, Canella Daniela Silva, Distribution and patterns of use of food additives in foods and beverages available in Brazilian supermarkets, Food & Function, 12, 17, 2021. Crossref

  6. Ghareghani Shiva, Sadighara Parisa, Mahsa Khodaei Sayedeh, Pirhadi Mohadeseh, Does Dietary Monosodium Glutamate Cause Neuro-toxicity on The Central Nervous System? A Review, Plant Biotechnology Persa, 4, 1, 2022. Crossref

  7. Nuthikattu Saivageethi, Milenkovic Dragan, Norman Jennifer E., Rutledge John, Villablanca Amparo, High Glycemia and Soluble Epoxide Hydrolase in Females: Differential Multiomics in Murine Brain Microvasculature, International Journal of Molecular Sciences, 23, 21, 2022. Crossref

  8. Norman Jennifer E., Nuthikattu Saivageethi, Milenkovic Dragan, Rutledge John C., Villablanca Amparo C., A high sucrose diet modifies brain oxylipins in a sex-dependent manner, Prostaglandins, Leukotrienes and Essential Fatty Acids, 186, 2022. Crossref

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