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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i3.10
pages 193-201

Therapeutic Efficacy of Rosa damascena Mill. on Acetaminophen-Induced Oxidative Stress in Albino Rats

Monika Sharma
Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India
Arvind Shakya
Indira Gandhi National Open University
Neetu Sharma
Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior, India
Sadhana Shrivastava
Reproductive Biology and Toxicology Labora¬tory, UNESCO Satellite Center of Trace Element Research, School of Studies in Zoology, Jiwaji University, Gwalior 474011, India
Sangeeta Shukla
School of Studies in Zoology, Jiwaji University, Gwalior 474011, India

ABSTRACT

Rosa damascena (RD) is a widely cultivated ornamental plant. It acts as an astringent, aperients, carminative, and refrigerant and is used in respiratory disorders, tonsillitis, eye disorders, migraines, gynecological disorders, and menopausal symptoms. The aim of this study is to investigate the hepatoprotective activity of the aqueous extract of RD flowers at different oral dose levels (250, 500, and 1000 mg/kg body weight) on acetaminophen (2 g/kg oral N-acetyl-p-aminophenol [APAP])−induced toxicity in rats. APAP administration altered various biochemical parameters, including serum transaminases, serum alkaline phosphatase, lactate dehydrogenase, albumin, bilirubin, urea and creatinine, hepatic lipid peroxidation, and reduced glutathione levels. Adenosine triphosphatase and glucose-6-phosphatase activity in the liver was decreased significantly in animals treated with APAP. These values are retrieved significantly by treatment with RD extract at all 3 doses in dose-dependant manner. Apart from these, histopathological changes also reveal the protective nature of the RD extract against acetaminophen−induced necrotic damage of hepatic tissues. In conclusion, these data suggest that the aqueous extract of RD may prevent hepatic damage from APAP−induced toxicity in rats and is likely to be mediated through its antioxidant activities.