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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2013008166
pages 115-129

Matrix Metalloproteinase-9 as a Potential Tumor Marker in Breast Cancer

Durga Prasad Nanda
Department of Surgical Oncology, Chittaranjan National Cancer Institute, Kolkata, India
Hrishikesh Sil
Department of Receptor Biology & Tumor Metastasis, Chittaranjan National Cancer, Institute, 37, S P Mukherjee Road, Kolkata - 700 026, West Bengal
Shuvojit Moulik
Department of Receptor Biology & Tumor Metastasis, Chittaranjan National Cancer, Institute, 37, S P Mukherjee Road, Kolkata - 700 026, West Bengal
Jaydip Biswas
Department of Surgical Oncology, Chittaranjan National Cancer Institute, Kolkata, India
Syamsundar Mandal
Department of Epidemiology and Biostatistics, Chittaranjan National Cancer Institute, Kolkata, India
Amitava Chatterjee
Department of Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata-700 026, India

ABSTRACT

This study aimed to detect the comparative expression and activity of matrix metalloproteinase-9 (MMP-9) and its correlation with known pathological parameters such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) in 81 malignant breast tumors and adjacent normal breast tissues and in blood sera of these patients from different clinical TNM stages (ductal carcinoma in situ to T4) of breast cancer. MMP-9 was highly expressed in node-positive tumors and the preoperative blood serum of patients, but MMP-9 activity was appreciably inhibited in blood serum samples collected after surgery. The mature form of MMP-9 (84 kD) was expressed only in clinical stage III tumors (T2−4). Appreciable reduction of tissue inhibitor of metalloproteinase 1, phosphorylation of epidermal growth factor receptor, and translocation of nuclear factor-κΒ suggested their possible role in MMP-9 activation in HER2-positive breast cancer Overexpression and activation of MMP-9 predicted a higher stage of hormone-sensitive ductal breast carcinoma. Downregulation of the endogenous inhibitor of MMP-9, tissue inhibitor of metalloproteinase 1, and translocation of the transcription factor nuclear factor-κΒ in tumors may have an appreciable role in the overexpression of MMP-9. However, MMP-9 activation was not correlated with expression of estrogen and progesterone receptors. Evaluation of MMP-9 expression may provide valuable information about breast cancer treatment.

KEY WORDS: breast cancer, IDC, MMP-9, ER, PR, HER2, TNM

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