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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Small Interfering RNAs (siRNAs) Targeting TGF-β1 mRNA Suppress Asbestos-Induced Expression of TGF-β1 and CTGF in Fibroblasts

Volume 28, Issue 2, 2009, pp. 109-119
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i2.30
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ABSTRACT

Interstitial lung disease (ILD) afflicts millions of people worldwide. ILD can be caused by a number of agents, including inhaled asbestos, and may ultimately result in respiratory failure and death. Currently, there are no effective treatments for ILD. Transforming growth factor-β1 (TGF-β1) is thought to play an important role in the development of pulmonary fibrosis, and asbestos has been shown to induce TGF-β1 expression in a murine model of ILD. To better define the role of TGF-β1 in ILD, we developed several small interfering RNAs (siRNAs) that target TGF-β1 mRNA for degradation. To assess the efficacy of each siRNA in reducing asbestos-induced TGF-β1 expression, Swiss 3T3 fibroblasts were transfected with TGF-β1 siRNAs and then treated with chrysotile asbestos for 48 h. Two independent siRNAs targeting TGF-β1 mRNA knocked-down asbestos-induced expression of TGF-β1 mRNA by 72−89% and protein by 70−84%. Interestingly, siRNA knockdown of TGF-β1 also reduced asbestos-induced expression of connective tissue growth factor (CTGF). CTGF can be upregulated by TGF-β1 and appears to play an important role in the development of pulmonary fibrosis. These results suggest that siRNAs could be effective in preventing or possibly arresting the progression of pulmonary fibrosis. Studies are underway in vivo to test this postulate.

CITED BY
  1. Liu Yuyuan, Li Weiwei, Liu Hong, Peng Youming, Yang Qiu, Xiao Li, Liu Yinghong, Liu Fuyou, Inhibition effect of small interfering RNA of connective tissue growth factor on the expression of extracellular matrix molecules in cultured human renal proximal tubular cells, Renal Failure, 36, 2, 2014. Crossref

  2. Tan Weijun, Tan Qiuyue, Wang Ting, Cheng Zhenshun, TGF-β1-Induced Pulmonary Fibroblasts Proliferation and Differentiation Are Inhibited by Antisense Oligodeoxynucleotide of Basic Fibroblast Growth Factor, CYTOLOGIA, 80, 3, 2015. Crossref

  3. Huang Min, Yang Huifang, Zhu Lingqin, Li Honghui, Zhou Jian, Zhou Zhijun, Inhibition of connective tissue growth factor attenuates paraquat-induced lung fibrosis in a human MRC-5 cell line, Environmental Toxicology, 31, 11, 2016. Crossref

  4. Yang Zhen, Li Qian, Yao Sanqiao, Zhang Ge, Xue Rong, Li Guoliang, Wang Yizheng, Wang Shixin, Wu Ruichang, Gao Hongsheng, Down-Regulation of miR-19a as a Biomarker for Early Detection of Silicosis, The Anatomical Record, 299, 9, 2016. Crossref

  5. Zhu Xiaojun, Gu Yishuo, Ma Wenjun, Gao Panjun, Liu Mengxuan, Xiao Pei, Wang Hongfei, Chen Juan, Li Tao, Biomarkers for Pulmonary Inflammation and Fibrosis and Lung Ventilation Function in Chinese Occupational Refractory Ceramic Fibers-Exposed Workers, International Journal of Environmental Research and Public Health, 15, 1, 2017. Crossref

  6. Ismaeel Ahmed, Kim Jeong-Su, Kirk Jeffrey S., Smith Robert S., Bohannon William T., Koutakis Panagiotis, Role of Transforming Growth Factor-β in Skeletal Muscle Fibrosis: A Review, International Journal of Molecular Sciences, 20, 10, 2019. Crossref

  7. Esebanmen Grace E., Langridge William H.R., Mechanism of chimeric vaccine stimulation of indoleamine 2,3-dioxygenase biosynthesis in human dendritic cells is independent of TGF-β signaling, Cellular Immunology, 319, 2017. Crossref

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