Library Subscription: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Gain Access(open in a new tab)
More
Purchase $35.00(open in a new tab) Check subscription Download MARC record(open in a new tab) Get Permissions(open in a new tab)

Repetitive Photodynamic Therapy of Malignant Brain Tumors

Volume 25, Issue 1-2, 2006, pp. 261-280
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.170
Get accessGet access
Henry Hirschberg
Beckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, 92617, USA
Dag R. Sorensen
Center for Comparative Medicine, Rikshospitalet, Oslo, Norway
Even Angell-Petersen
Department of Surgical Oncology, The Norwegian Radium Hospital, Oslo, Norway
Qian Peng
Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
Bruce Tromberg
Beckman Laser Institute, University of California, 1002 Health Science Road, East Irvine, CA 92612
Chung-Ho Sun
Beckman Laser Institute, University of California, 1002 Health Science Road, East Irvine, CA 92612
Signe Spetalen
Department of Pathology, Ullevaal University Hospital, Oslo, Norway
Steen J. Madsen
Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, 4505 S. Maryland Pkwy., Box 453037, Las Vegas, NV 89154, USA

ABSTRACT

The probability of achieving local control with current single-shot, intraoperative photodynamic therapy (PDT) treatments of intracerebral gliomas seems improbable due to the length of time required to deliver adequate light fluences to depths of 1−2 cm in the resection margin. Additionally, due to the short doubling time of many malignant gliomas, the kill rate per cell doubling indicates that it seems unlikely that a single treatment would be sufficient to prevent tumor recurrence. Multiple repetitive treatments would therefore seem required. In this publication we primarily review our work examining the effects of repetitive PDT on malignant brain tumor cells both in vitro and in vivo. The in vitro therapy response of human and rat glioma spheroids to 5-aminolevulinic acid (ALA)-mediated PDT in repetitive form was investigated. The results indicated that PDT repeated at relatively long intervals (weeks) was more effective at inhibiting spheroid growth than either daily fractionated PDT or single-treatment regimes. The in vivo response to repetitive treatment was evaluated in a rodent glioma model where BT4C cell line tumors were established in the brains of inbred BD-IX rats. Microfluorometry of frozen tissue sections showed that PpIX is produced with a 10−20:1 tumor to normal tissue selectivity ratio 4 hr after ALA injection. Preliminary evidence of increased efficacy of repetitive PDT and low fluence rate treatment is presented.

CITED BY

  1. Milla Sanabria Laura, Rodríguez Matías Exequiel, Cogno Ingrid Sol, Rumie Vittar Natalia Belén, Pansa María Florencia, Lamberti María Julia, Rivarola Viviana Alicia, Direct and indirect photodynamic therapy effects on the cellular and molecular components of the tumor microenvironment, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1835, 1, 2013. Crossref

  2. Smith Luke G.F., Nakano Ichiro, Fluorescence-Guided Brain Tumor Surgery, World Neurosurgery, 78, 6, 2012. Crossref

  3. Noell Susan, Feigl Guenther C., Serifi Dzenan, Mayer Daniel, Naumann Ulrike, Göbel Werner, Ehrhardt André, Ritz Rainer, Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model, Photodiagnosis and Photodynamic Therapy, 10, 4, 2013. Crossref

  4. Sailer Reinhard, Strauss Wolfgang S. L., Wagner Michael, Emmert Helmut, Schneckenburger Herbert, Relation between intracellular location and photodynamic efficacy of 5-aminolevulinic acid-induced protoporphyrin IXin vitro. Comparison between human glioblastoma cells and other cancer cell lines, Photochem. Photobiol. Sci., 6, 2, 2007. Crossref

  5. Hirschberg Henry, Uzal Francisco A., Chighvinadze David, Zhang Michelle J., Peng Qian, Madsen Steen J., Disruption of the blood-brain barrier following ALA-mediated photodynamic therapy, Lasers in Surgery and Medicine, 40, 8, 2008. Crossref

  6. Tetard Marie-Charlotte, Vermandel Maximilien, Mordon Serge, Lejeune Jean-Paul, Reyns Nicolas, Experimental use of photodynamic therapy in high grade gliomas: A review focused on 5-aminolevulinic acid, Photodiagnosis and Photodynamic Therapy, 11, 3, 2014. Crossref

  7. Kostron Herwig, Fiegele Thomas, Akatuna Emra, Combination of FOSCAN® mediated fluorescence guided resection and photodynamic treatment as new therapeutic concept for malignant brain tumors, Medical Laser Application, 21, 4, 2006. Crossref

  8. Fleshker Shimrit, Preise Dina, Kalchenko Vyacheslav, Scherz Avigdor, Salomon Yoram, Prompt Assessment of WST11-VTP Outcome Using Luciferase Transfected Tumors Enables Second Treatment and Increase in Overall Therapeutic Rate, Photochemistry and Photobiology, 84, 5, 2008. Crossref

  9. Mathews Marlon S., Angell-Petersen Even, Sanchez Rogelio, Sun Chung-Ho, Vo Van, Hirschberg Henry, Madsen Steen J., The effects of ultra low fluence rate single and repetitive photodynamic therapy on glioma spheroids, Lasers in Surgery and Medicine, 41, 8, 2009. Crossref

  10. Madsen Steen J., Mathews Marlon S., Angell-Petersen Even, Sun Chung-Ho, Vo Van, Sanchez Rogelio, Hirschberg Henry, Motexafin gadolinium enhances the efficacy of aminolevulinic acid mediated-photodynamic therapy in human glioma spheroids, Journal of Neuro-Oncology, 91, 2, 2009. Crossref

  11. Hirschberg Henry, Lasers in Diagnostics and Treatment of Brain Diseases, in Biomedical Photonics Handbook, Second Edition, 2014. Crossref

  12. Guo Han-Wen, Wang Hsing-Wen, Ho Meng-Huan, Lee Meng-Ting, Chen Chih-Lei, Chuang Ching-Sang, Lin Yusin, 5.4L:Late-News Paper: ALA Mediated Metronomic Photodynamic Therapy in Mouse Gliomas Model using Organic Light Emitting Diode, SID Symposium Digest of Technical Papers, 45, 1, 2014. Crossref

  13. Millon Stacy R., Ostrander Julie H., Yazdanfar Siavash, Brown J. Quincy, Bender Janelle E., Rajeha Anita, Ramanujam Nirmala, Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes, Journal of Biomedical Optics, 15, 1, 2010. Crossref

  14. Madsen Steen J., Hirschberg Henry, Site-specific opening of the blood-brain barrier, Journal of Biophotonics, 3, 5-6, 2010. Crossref

  15. Davies Nick, Wilson Brian C., Interstitial in vivo ALA-PpIX mediated metronomic photodynamic therapy (mPDT) using the CNS-1 astrocytoma with bioluminescence monitoring, Photodiagnosis and Photodynamic Therapy, 4, 3, 2007. Crossref

  16. Tsurubuchi Takao, Zaboronok Alexander, Yamamoto Tetsuya, Nakai Kei, Yoshida Fumiyo, Shirakawa Makoto, Matsuda Masahide, Matsumura Akira, The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema—In vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium, Photodiagnosis and Photodynamic Therapy, 6, 1, 2009. Crossref

  17. Rodríguez Matías E., Cogno Ingrid S., Milla Sanabria Laura S., Morán Yanina S., Rivarola Viviana A., Heat shock proteins in the context of photodynamic therapy: autophagy, apoptosis and immunogenic cell death, Photochemical & Photobiological Sciences, 15, 9, 2016. Crossref

  18. Fan Zhichao, Cui Xiaojun, Wei Dan, Liu Wei, Li Buhong, He Hao, Ye Huamao, Zhu Naishuo, Wei Xunbin, eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy, Scientific Reports, 6, 1, 2016. Crossref

  19. Kostron Herwig, Photodynamic Diagnosis and Therapy and the Brain, in Photodynamic Therapy, 635, 2010. Crossref

  20. Mathews Marlon S., Abookasis David, Linskey Mark E., Laser/Light Applications in Neurology and Neurosurgery, in Lasers in Dermatology and Medicine, 2011. Crossref

  21. Kostron Herwig, Photodynamic Diagnosis and Therapy for Brain Malignancies from the Bench to Clinical Application, in Photodynamic Therapy, 2014. Crossref

  22. Newman J. Robert, Rosenthal Eben L., Optical Imaging of Primary Tumors, in Optical Imaging of Cancer, 2010. Crossref

  23. Mahmoudi K., Garvey K. L., Bouras A., Cramer G., Stepp H., Jesu Raj J. G., Bozec D., Busch T. M., Hadjipanayis C. G., 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas, Journal of Neuro-Oncology, 141, 3, 2019. Crossref

  24. Yanovsky Rebecca L., Bartenstein Diana W., Rogers Gary S., Isakoff Steven J., Chen Steven T., Photodynamic therapy for solid tumors: A review of the literature, Photodermatology, Photoimmunology & Photomedicine, 35, 5, 2019. Crossref

  25. Shin Diane, Nguyen Lina, T Le Mai, Ju David, N Le Jimmy, Berg Kristian, Hirschberg Henry, The effects of low irradiance long duration photochemical internalization on glioma spheroids, Photodiagnosis and Photodynamic Therapy, 26, 2019. Crossref

  26. Ibarra Luis Exequiel, Vilchez María Laura, Caverzán Matías Daniel, Milla Sanabria Laura Natalia, Understanding the glioblastoma tumor biology to optimize photodynamic therapy: From molecular to cellular events, Journal of Neuroscience Research, 99, 4, 2021. Crossref

  27. Nguyen Lina, Potma Eric O., Le Jimmy N., Johnson Julie, Romena Gabrielle, Peng Qian, Berg Kristian, Hirschberg Henry, Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier, Lasers in Medical Science, 36, 5, 2021. Crossref

  28. Vilchez María L., Rodríguez Lucía B., Palacios Rodrigo E., Prucca César G., Caverzán Matías D., Caputto Beatriz L., Rivarola Viviana A., Milla Sanabria Laura N., Isolation and initial characterization of human glioblastoma cells resistant to photodynamic therapy, Photodiagnosis and Photodynamic Therapy, 33, 2021. Crossref

  29. D'Este Francesca, Della Pietra Emilia, Badillo Pazmay Gretta Veronica, Xodo Luigi E., Rapozzi Valentina, Role of nitric oxide in the response to photooxidative stress in prostate cancer cells, Biochemical Pharmacology, 182, 2020. Crossref

  30. Mao Chengqiong, Zhao Yan, Li Fang, Li Zibo, Tian Shaomin, Debinski Waldemar, Ming Xin, P-glycoprotein targeted and near-infrared light-guided depletion of chemoresistant tumors, Journal of Controlled Release, 286, 2018. Crossref

  31. Zuluaga Maria-Fernanda, Sekkat Nawal, Gabriel Doris, van den Bergh Hubert, Lange Norbert, Selective Photodetection and Photodynamic Therapy for Prostate Cancer through Targeting of Proteolytic Activity, Molecular Cancer Therapeutics, 12, 3, 2013. Crossref

  32. Guo Han-Wen, Lin Liang-Ting, Chen Po-Hsiung, Ho Meng-Huan, Huang Wan-Ting, Lee Yi-Jang, Chiou Shih-Hwa, Hsieh Yei-San, Dong Chen-Yuan, Wang Hsing-Wen, Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED), Photodiagnosis and Photodynamic Therapy, 12, 3, 2015. Crossref

  33. Ferrés Abel, Di Somma Alberto, Mosteiro Alejandra, Topczewski Thomaz Eduardo, Roldán Pedro, Pedrosa Leire, Diao Diouldé, Pineda Estela, Sierra Àngels, Enseñat Joaquim, González-Sánchez José Juan, Photodynamic therapy in glioblastoma: Detection of intraoperative inadvertent 5-ALA mediated photodynamic therapeutical effect after gross total resection, Frontiers in Oncology, 12, 2022. Crossref

1431 Article views 30 Article downloads Metrics
1431 VIEWS 30 DOWNLOADS 33 Crossref CITATIONS Google
Scholar CITATIONS

Articles with similar content:

Fluorescence Monitoring of a Topically Applied Liposomal Temoporfin Formulation and Photodynamic Therapy of Nonpigmented Skin Malignancies Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Linda Persson, Johan Axelsson, Tilmann Trebst, Stefan Andersson-Engels, Susanna Grafe, Jenny Svensson, Sune Svanberg, Ann Johansson, Katarina Svanberg, Niels Bendsoe
Bystander Effect of Conditioned Medium from Low and High Doses of γ-irradiated Human Leukemic Cells on Normal Lymphocytes and Cancer Cells Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 4
Amit Kumar, Kaushala Prasad Mishra, Badri Narain Pandey, Manjoor Ali
Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90 Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 2
Brad A. Hartl, Henry Hirschberg, Laura Marcu, Simon R. Cherry
Photodynamic Therapy of Nodular Basal Cell Carcinoma with Multifiber Contact Light Delivery Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
A. Derjabo, Unne Stenram, Stefan Andersson-Engels, Marcelo Soto Thompson, T. Johansson, J. Spigulis, Sune Svanberg, Sara Palsson, Katarina Svanberg, Niels Bendsoe, J. Kapostins
Pretreatment of Plantar Warts with Azone Enhances the Effect of 5-Aminolevulinic Acid Photodynamic Therapy Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Jolanta Ziolkowska, Piotr Ziolkowski, Maciej Siewinski, Beata J. Osiecka, Hanna Gerber-Leszczyszyn, Andrzej Bronowicz

Latest Issue

A Review on Protease Inhibitors of Herbal Origin to Combat Malignancy Sanjib Bhattacharya Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small-Cell Lung Cancer Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala Treatment Strategy for Breast Benign Intraductal Papilloma: A Meta-Analysis Congkun Lou, Wenhsin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer Deqin Liu, Renyin Luo, Qian Zhou, Mei Li Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape Jian Zhu, Yao Ma

Forthcoming Articles

LncRNA LINC01278 regulates the prognosis and related mechanisms of gastric cancer by targeting miR-129-5p Zhenhua Wang, Zhengliang Li, Xiaojing Liu, Jundong Wang, Jiaxi Wang, Guoxiang Jiang, Haizhou Yu FBXO45 expression levels Correlation with cancer severity by ZEB1 ubiquitin in non-small cell lung cancer Bingwei Dong LncRNA AGAP11 suppresses lung adenocarcinoma progression by miR-494-3p and predicts prognosis Ye He, Ya Lin , Chunge Dong, Jie Zhang, Yangli Zhu Treatment strategy for breast benign intraductal papilloma: A Meta-Analysis Congkun Lou, Wenxin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small Cell Lung Cancer (NSCLC) Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala A review on protease inhibitors of herbal origin to combat malignancy Sanjib Bhattacharya
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain