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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.190
pages 293-306

Mechanism of Radiosensitization by Porphyrins

Zivile Luksiene
Institute of Materials Sciences and Applied Research, Vilnius University, Sauletekio 9, LT-10223, Vilnius, Lithuania
Danute Labeikyte
Department of Biochemistry and Biophysics, Vilnius University, M. K. Ciurlionio 22, LT-03101, Vilnius, Lithuania
Benediktas Juodka
Department of Biochemistry and Biophysics, Vilnius University, M. K. Ciurlionio 22, LT-03101, Vilnius, Lithuania
Johan Moan
Department of Radiation Biophysics, Institute for Cancer Research, Rikshospital-Radiumhospital HF and Plasma/Room Physics, University of Oslo; lnstitute of Physics, University of Oslo, Blindern, Oslo, Norway

ABSTRACT

According to our previous data, hematoporphyrin dimethyl ether (HPde) at concentrations useful for photodynamic therapy can radiosensitize aggressive Ehrlich ascite carcinoma (EAT) to 2Gy irradiation inducing total tumour growth inhibition. The aim of this study was to further investigate the possible mechanism of radiosensitization of EAT by dicarboxylic porphyrin-HPde. Our results reveal that HPde is inducing several rearrangements in the EAT cells: 1.2 × 10−6 M of the photosensitizer diminishes the number of cells in mitosis by a factor of 3, increases the number of cells in the S phase of the cell cycle, modifies the activities of antioxidant enzymes glutation S-transferase (GST) and DT-diaphorase (DTD), and eventually induces slight apoptosis. Moreover, it was shown that HPde is a ligand of peripheral benzodiazepine receptor (PBR). Named "house keeper," PBR is usually responsible for all these perturbations, which, in our case, act in concert with the following ionizing radiation, producing the interaction of two antiproliferative/destructive factors.


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