Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
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Bioassay-Guided Isolation of Antimutagenic Factors from Fruits of Terminalia Bellerica
ABSTRACT
In the course of our search for novel polyphenolic antimutagenic agents from medicinal plants, we examined water, acetone, and chloroform extracts of Terminalia bellerica for their antimutagenic potency using the Ames Salmonella/microsome assay. Acetone extract exhibited variable inhibitory activity of 65.6%, and 69.7% with 4–O–nitrophenylenediamine (NPD) and sodium azide, respectively (as direct-acting mutagens), and 81.4% with 2–aminofluorene (2AF) (an S9-dependent mutagen), in the preincubation mode of experimentation. Inhibition with chloroform and water extracts was rather insignificant. Studies are well underway to isolate and identify the active polyphenolic compounds from acetone extract, which could be used as effective chemopreventive agents in the future.
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Srinivasa Rao Boddapati, Chandrasekaran C. V., Srikanth H. S., Sasikumar Murugan, Edwin Jothie R., Haseena Begum, Bharathi Bethapudi, Selvam Ramasamy, Prashanth D’Souza, Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements, Journal of Toxicology, 2018, 2018. Crossref
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Sharma Panshul, Verma Kapil Kumar, Raj Hans, Thakur Nutan, A review on ethnobotany, phytochemistry and pharmacology on Terminalia belerica (Bibhitaki), Journal of Drug Delivery and Therapeutics, 11, 1-s, 2021. Crossref