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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Curcumin Exhibits Antimetastatic Properties by Modulating Integrin Receptors, Collagenase Activity, and Expression of Nm23 and E-Cadherin

Volume 22, Issue 1, 2003, 10 pages
DOI: 10.1615/JEnvPathToxOncol.v22.i1.50
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ABSTRACT

Curcumin (diferuloyl methane), the major pigment from the rhizome of Curcuma longa L., has been widely studied for its tumor-inhibiting properties. Recent studies indicate that curcumin can modify cell receptor binding; it also affects intracellular signaling reactions. Curcumin-treated B16F10 melanoma cells formed eight-fold fewer lung metastases in C57BL6 mice. In the cell adhesion assays, curcumin-treated cells showed a dose-dependent reduction in their binding to four extracellular matrix (ECM) proteins. The binding to fibronectin, vitronectin, and collagen IV decreased by over 50% in 24 hours, and by 100% after 48 hours of curcumin treatment; it persisted at this level even after 15 days of cultivating cells in curcumin-free medium. Curcumin-treated cells showed a marked reduction in the expression of a5b1 and avb3 integrin receptors. In addition, curcumin treatment inhibited pp125 focal adhesion kinase (FAK), tyrosine phosphorylation of a 120 kD protein, and collagenase activity. Curcumin enhances the expression of antimetastatic proteins, tissue inhibitor metalloproteinase (TIMP)-2, nonmetastatic gene 23 (Nm23), and E-cadherin. In this article we report on the effect of curcumin on the expression of integrin, TIMP-2, Nm23, E-cadherin, adhesion, and metalloproteinase activity.

CITED BY
  1. Banerjee S., Bandyopadh G., Chattopadh K., Chattopadh B.D., Amelioration of Nicotine-Induced Damage of Blood Cells in Protein Malnourished Female Rats by Curcumin, International Journal of Pharmacology, 6, 4, 2010. Crossref

  2. Zhang Li, Cheng Xian, Gao Yanyan, Zhang Chiyu, Bao Jiandong, Guan Haixia, Yu Huixin, Lu Rongrong, Xu Qiang, Sun Yang, Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-β/Smad2/3 signaling pathway, Experimental Cell Research, 341, 2, 2016. Crossref

  3. Tafrihi Majid, Nakhaei Sistani Roohollah, E-Cadherin/β-Catenin Complex: A Target for Anticancer and Antimetastasis Plants/Plant-derived Compounds, Nutrition and Cancer, 69, 5, 2017. Crossref

  4. Zhang Ye, Enhancing Antidepressant Effect of Poloxamer/Chitosan Thermosensitive Gel Containing Curcumin-Cyclodextrin Inclusion Complex, International Journal of Polymer Science, 2018, 2018. Crossref

  5. Tavakoli Fatemeh, Jahanban-Esfahlan Rana, Seidi Khaled, Jabbari Masoumeh, Behzadi Ramezan, Pilehvar-Soltanahmadi Younes, Zarghami Nosratollah, Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma tumour model, Artificial Cells, Nanomedicine, and Biotechnology, 46, sup2, 2018. Crossref

  6. Sajadimajd Soraya, Bahramsoltani Roodabeh, Iranpanah Amin, Kumar Patra Jayanta, Das Gitishree, Gouda Sushanto, Rahimi Roja, Rezaeiamiri Elnaz, Cao Hui, Giampieri Francesca, Battino Maurizio, Tundis Rosa, Campos Maria G., Farzaei Mohammad Hosein, Xiao Jianbo, Advances on Natural Polyphenols as Anticancer Agents for Skin Cancer, Pharmacological Research, 151, 2020. Crossref

  7. Mansouri Kamran, Rasoulpoor Shna, Daneshkhah Alireza, Abolfathi Soroush, Salari Nader, Mohammadi Masoud, Rasoulpoor Shabnam, Shabani Shervin, Clinical effects of curcumin in enhancing cancer therapy: A systematic review, BMC Cancer, 20, 1, 2020. Crossref

  8. Chen Huei-Wen, Lee Jen-Yi, Huang Ji-Ying, Wang Chi-Chung, Chen Wan-Jiun, Su Sheng-Fang, Huang Chia-Wen, Ho Chao-Chi, Chen Jeremy J.W., Tsai Meng-Feng, Yu Sung-Liang, Yang Pan-Chyr, Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1, Cancer Research, 68, 18, 2008. Crossref

  9. Dinu-Pirvu Cristina Elena, Cocos Florentina Iuliana, Anuta Valentina, Ghica Mihaela Violeta, Popa Lacramioara, Plant Secondary Metabolites: Natural Compounds as Cosmetic Ingredients and Their Potential Activity in Skin Cancer, in Plant Secondary Metabolites, 2022. Crossref

  10. Feltrin Felipe da Silva, Agner Tamara, Sayer Claudia, Lona Liliane Maria Ferrareso, Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies, Advances in Colloid and Interface Science, 300, 2022. Crossref

  11. Shen Guoxiang, Xu Changjiang, Hu Rong, Jain Mohit R., Gopalkrishnan Avantika, Nair Sujit, Huang Mou-Tuan, Chan Jefferson Y., Kong Ah-Ng Tony, Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin, Molecular Cancer Therapeutics, 5, 1, 2006. Crossref

  12. Prasad Sahdeo, Saha Priyanka, Chatterjee Bilash, Chaudhary Anis Ahmad, Lall Rajiv, Srivastava Amit K, Complexity of Tumor Microenvironment: Therapeutic Role of Curcumin and Its Metabolites, Nutrition and Cancer, 2022. Crossref

  13. Wang Shimeng, Gao Xinliang, Li Jialin, Wei Shixiong, Shao Yifeng, Yin Yipeng, Zhang Duo, Tang Mingbo, The anticancer effects of curcumin and clinical research progress on its effects on esophageal cancer, Frontiers in Pharmacology, 13, 2022. Crossref

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