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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Carcinogenicity of Nickel Is the Result of Its Binding to RNA and Not to DNA

Volume 22, Issue 1, 2003, 11 pages
DOI: 10.1615/JEnvPathToxOncol.v22.i1.30
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ABSTRACT

In vivo and in vitro studies have shown for the first time that nickel binds maximally to RNA as compared to DNA. The distribution of radiolabeled nickel in various subcellular fractions of liver, kidney, spleen, and lungs of rats has shown that it was mostly localized in the nuclear fraction of each organ, where it was bound to RNA and not to DNA or to proteins. Significant differences between infrared (IR) spectra of RNA and RNA incubated with nickel chloride further corroborate these findings. Parallel experiments with DNA did not show any such effects. Nickel may, therefore, be acting as a carcinogen by controlling gene expression post-transcriptionally.

CITED BY
  1. Hfaiedh Najla, Allagui Mohamed Salah, Croute Françoise, Geurmazi Fadhel, el Feki Abdelfettah, Carreau Serge, Incidences de la restriction calorique et du Nickel sur l’aromatase testiculaire du rat, Andrologie, 17, 4, 2007. Crossref

  2. Al-Attar Atef M., The Influences of Nickel Exposure on Selected Physiological Parameters and Gill Structure in the Teleost Fish, Oreochromis niloticus, Journal of Biological Sciences, 7, 1, 2006. Crossref

  3. Hfaïedh Najla, Salah Allaqui Mohamed, Croute Françoise, Soleilhavoup Jean-Pierre, Jammoussi Kamel, Makni Ayadi Fatma, Kammoun Abdelaziz, El Feki Abdelfattah, Interaction du jeûne intermittent sur les effets cytotoxiques rénaux du nickel chez le rat pubère, Comptes Rendus Biologies, 328, 7, 2005. Crossref

  4. Dahdouh Faouzi, Raane Maximilian, Thévenod Frank, Lee Wing-Kee, Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1, Archives of Toxicology, 88, 4, 2014. Crossref

  5. Dohnalova Lucie, Bucek Pavel, Vobornik Petr, Dohnal Vlastimil, Determination of nickel in hydrogenated fats and selected chocolate bars in Czech Republic, Food Chemistry, 217, 2017. Crossref

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