Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
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Carcinogenicity of Nickel Is the Result of Its Binding to RNA and Not to DNA
ABSTRACT
In vivo and in vitro studies have shown for the first time that nickel binds maximally to RNA as compared to DNA. The distribution of radiolabeled nickel in various subcellular fractions of liver, kidney, spleen, and lungs of rats has shown that it was mostly localized in the nuclear fraction of each organ, where it was bound to RNA and not to DNA or to proteins. Significant differences between infrared (IR) spectra of RNA and RNA incubated with nickel chloride further corroborate these findings. Parallel experiments with DNA did not show any such effects. Nickel may, therefore, be acting as a carcinogen by controlling gene expression post-transcriptionally.
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Al-Attar Atef M., The Influences of Nickel Exposure on Selected Physiological Parameters and Gill Structure in the Teleost Fish, Oreochromis niloticus, Journal of Biological Sciences, 7, 1, 2006. Crossref
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Dohnalova Lucie, Bucek Pavel, Vobornik Petr, Dohnal Vlastimil, Determination of nickel in hydrogenated fats and selected chocolate bars in Czech Republic, Food Chemistry, 217, 2017. Crossref