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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Antibacterial Medicinal Plants Equiseti Herba and Ononidis Radix Modulate Micronucleus Formation in Human Lymphocytes In Vitro

Volume 22, Issue 1, 2003, 8 pages
DOI: 10.1615/JEnvPathToxOncol.v22.i1.40
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ABSTRACT

We assessed the in vitro cytogenetic effects of extracts of the commonly used medicinal plants Equiseti herba, Ononidis radix, and Uva ursi on irradiated human blood lymphocytes. We examined the acquired micronucleus formation in unirradiated and irradiated samples of cultured blood lymphocytes using the cytochalasin block micronucleus test (CBMN). Centromere-positive micronuclei were identified by fluorescence in situ hybridization using a DNA probe labeled with a-satellite digogsigenin. Equiseti herba had weak clastogenic properties, increasing the yield of micronuclei in unirradiated samples and reducing the level of radiation-induced micronuclei in a concentration-dependent manner. In the control, unirradiated samples, 36.8% of micronuclei were centromerepositive (MNC+), while in the irradiated ones the percentage of MNC+ ranged from 10.8-15.3%, indicating a clastogenic mechanism for the micronuclei formation. Ononidis radix was a strong clastogen and radiosensitizer, rapidly increasing the yield of micronuclei in unirradiated samples up to 5-fold and potentiating the yield of radiation-induced micronuclei up to 1.7-fold. In cultures treated with Ononidis radix, the percentage of MNC+ micronuclei ranged from 18.8 to 23.8%, indicating that micronuclei originated by a clastogenic mechanism. Uva ursi did not affect the yield of micronuclei either in unirradiated or in irradiated samples. The micronucleus formation assay is a reliable screen for plant extracts and purified compounds, for the identification of compounds that might either inhibit clastogenesis or potentiate radiotherapy for malignancy.

CITED BY
  1. Kuntić Vesna S., Stanković Miroslava B., Vujić Zorica B., Brborić Jasmina S., Uskoković-Marković Snežana M., Radioprotectors - the Evergreen Topic, Chemistry & Biodiversity, 10, 10, 2013. Crossref

  2. Štajner Dubravka, Popović Boris M., Čanadanović-Brunet Jasna, Anačkov Goran, ExploringEquisetum arvenseL.,Equisetum ramosissimumL. andEquisetum telmateiaL. as sources of natural antioxidants, Phytotherapy Research, 23, 4, 2009. Crossref

  3. Milovanović Vesna, Radulović Niko, Todorović Zoran, Stanković Miroslava, Stojanović Gordana, Antioxidant, Antimicrobial and Genotoxicity Screening of Hydro-alcoholic Extracts of Five Serbian Equisetum Species, Plant Foods for Human Nutrition, 62, 3, 2007. Crossref

  4. Materia Medica, in Veterinary Herbal Medicine, 2007. Crossref

  5. Harutyunyan Karina, Balayan Karine, Tadevosyan Gohar, Hayrapetyan Manush, Musayelyan Ruzanna, Grigoryan Ruzanna, Khondkaryan Lusine, Sarkisyan Natalya, Babayan Nelly, Genotoxic potential of selected medicinal plant extracts in human whole blood cultures, Journal of Herbmed Pharmacology, 8, 2, 2019. Crossref

  6. Joksić Gordana, Tričković Jelena Filipović, Joksić Ivana, Potential of Gentiana lutea for the Treatment of Obesity-associated Diseases, Current Pharmaceutical Design, 25, 18, 2019. Crossref

  7. Gallo Francesca R., Multari Giuseppina, Federici Elena, Palazzino Giovanna, Giambenedetti Massimo, Petitto Valentina, Poli Ferruccio, Nicoletti Marcello, Chemical fingerprinting of Equisetum arvense L. using HPTLC densitometry and HPLC, Natural Product Research, 25, 13, 2011. Crossref

  8. Jurica Karlo, Karačonji Irena Brčić, Benković Vesna, Kopjar Nevenka, In vitro assessment of the cytotoxic, DNA damaging, and cytogenetic effects of hydroquinone in human peripheral blood lymphocytes, Archives of Industrial Hygiene and Toxicology, 68, 4, 2017. Crossref

  9. Dormousoglou Margarita, Efthimiou Ioanna, Antonopoulou Maria, Fetzer Damian L., Hamerski Fabiane, Corazza Marcos L., Papadaki Maria, Santzouk Samir, Dailianis Stefanos, Vlastos Dimitris, Investigation of the Genotoxic, Antigenotoxic and Antioxidant Profile of Different Extracts from Equisetum arvense L., Antioxidants, 11, 7, 2022. Crossref

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