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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Studies on Correlation of Antimutagenic and Antiproliferative Activities of Juglans regia L.

Volume 22, Issue 1, 2003, 10 pages
DOI: 10.1615/JEnvPathToxOncol.v22.i1.60
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ABSTRACT

We investigated the effect of water and acetone extract of Juglans regia L. to evaluate its antimutagenic and antiproliferative activities. The antimutagenic study using TA98 and TA100 tester strains of Salmonella revealed the water and acetone extracts to be more effective than the benzene and chloroform extracts in inhibiting the revertants induced by 2–aminoflourene (2AF) in TA100 tester strains. The most effective extracts in the Ames assay were further evaluated using the Lucifer luciferase assay and in time course studies for antiproliferative activities using the Hoechst staining to observe apoptotic cell deaths. The acetone extract showed a correlation of antimutagenic activities in the Ames assay with its antiproliferative effect in different cell lines, while the water extract exerted its effect distinctly in each cell line. Further studies are still needed to evaluate the cytotoxicity in experiments carried out in vivo.

CITED BY
  1. Kaileh Mary, Berghe Wim Vanden, Boone Elke, Essawi Tamer, Haegeman Guy, Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity, Journal of Ethnopharmacology, 113, 3, 2007. Crossref

  2. Carvalho Márcia, Ferreira Pedro J., Mendes Vanda S., Silva Renata, Pereira José A., Jerónimo Carmen, Silva Branca M., Human cancer cell antiproliferative and antioxidant activities of Juglans regia L., Food and Chemical Toxicology, 48, 1, 2010. Crossref

  3. Vahdati K., Sarikhani Khorami S., Arab M.M., Walnut: a potential multipurpose nut crop for reclaiming deteriorated lands and environment, Acta Horticulturae, 1190, 2018. Crossref

  4. Haque R, Bin-Hafeez B, Parvez S, Pandey S, Sayeed I, Ali M, Raisuddin S, Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamideinduced biochemical toxicity, Human & Experimental Toxicology, 22, 9, 2003. Crossref

  5. Asgary Sedigheh, Parkhideh Sahar, Solhpour Amirreza, Madani Hossein, Mahzouni Parvin, Rahimi Parivash, Effect of Ethanolic Extract of Juglans regia L. on Blood Sugar in Diabetes-Induced Rats, Journal of Medicinal Food, 11, 3, 2008. Crossref

  6. Chudhary Zarghouna, Khera Rasheed Ahmad, Hanif Muhammad Asif, Ayub Muhammad Adnan, Hamrouni Lamia, Walnut, in Medicinal Plants of South Asia, 2020. Crossref

  7. D’Angeli Floriana, Malfa Giuseppe Antonio, Garozzo Adriana, Li Volti Giovanni, Genovese Carlo, Stivala Aldo, Nicolosi Daria, Attanasio Francesco, Bellia Francesco, Ronsisvalle Simone, Acquaviva Rosaria, Antimicrobial, Antioxidant, and Cytotoxic Activities of Juglans regia L. Pellicle Extract, Antibiotics, 10, 2, 2021. Crossref

  8. Bakrim Saad, Benkhaira Nesrine, Bourais Ilhame, Benali Taoufiq, Lee Learn-Han, El Omari Nasreddine, Sheikh Ryan A., Goh Khang Wen, Ming Long Chiau, Bouyahya Abdelhakim, Health Benefits and Pharmacological Properties of Stigmasterol, Antioxidants, 11, 10, 2022. Crossref

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