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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Ipobscurine, an Indole Alkaloid from Ipomoea obscura, Inhibits Tumor Cell Invasion and Experimental Metastasis by Inducing Apoptosis

Volume 30, Issue 2, 2011, pp. 163-178
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i2.70
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ABSTRACT

In the present study, we demonstrate that ipobscurine, an indole alkaloid fraction isolated from Ipomoea obscura, can reduce the formation of B16F-10 melanoma–induced metastatic nodules and inhibit the proliferation, migration, and invasion of B16F-10 melanoma cells in vitro, possibly by inhibiting pro-metastatic genes such as matrix metalloproteinases (MMPs) and inflammatory mediators such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and pro-inflammatory cytokines. Ipobscurine may also promote apoptosis by up-regulating pro-apoptotic molecules such as caspase-3, p53, and Bax and by down-regulating anti-apoptotic Bcl-2. In addition, we have observed that ipobscurine suppresses various transcription factors such as nuclear factor-κB (NF-κB) and activator protein, which are possibly associated with the suppression of apoptosis in cancer cells. Ipobscurine has also been shown to inhibit cell growth with arrest at G1 and reduce transition to the S and G2/M phases of the cell cycle.

CITED BY
  1. AlQathama A., Prieto J. M., Natural products with therapeutic potential in melanoma metastasis, Natural Product Reports, 32, 8, 2015. Crossref

  2. Özenver Nadire, Efferth Thomas, Small molecule inhibitors and stimulators of inducible nitric oxide synthase in cancer cells from natural origin (phytochemicals, marine compounds, antibiotics), Biochemical Pharmacology, 176, 2020. Crossref

  3. Ramu Arunkumar, Kathiresan Suresh, Ramadoss Hemavardhini, Nallu Anandhi, Kaliyan Ramachandran, Azamuthu Theerthu, Gramine attenuates EGFR-mediated inflammation and cell proliferation in oral carcinogenesis via regulation of NF-κB and STAT3 signaling, Biomedicine & Pharmacotherapy, 98, 2018. Crossref

  4. Fakhri Sajad, Moradi Seyed Zachariah, Yarmohammadi Akram, Narimani Fatemeh, Wallace Carly E., Bishayee Anupam, Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy, Frontiers in Oncology, 12, 2022. Crossref

  5. Fan Dacheng, Sun Weizhi, Qiu Peiju, Wu Zhiyong, Li Yantuan, Wan Shengbiao, Jiang Tao, Zhang Lijuan, Exploring stereoselectivity of 3-indolyl cyclopent[b]indoles: A parallel synthesis and anti-EGFR study on human cancer cells, European Journal of Medicinal Chemistry, 74, 2014. Crossref

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