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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Time Course of Pulmonary Response of Rats to Inhalation of Crystalline Silica: Histological Results and Biochemical Indices of Damage, Lipidosis, and Fibrosis

Volume 20, Issue Suppl.1, 2001, 14 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v20.iSuppl.1.10
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ABSTRACT

Previous studies have determined that a-quartz (crystalline silica) can cause pulmonary inflammation, damage, and fibrosis. However, the temporal relationship between silica inhalation and pulmonary inflammation, damage, and fibrosis has not been fully examined. To address this gap in our knowledge of silica-induced pulmonary fibrosis, a chronic inhalation study using rats was designed. Specifically, rats were exposed to a silica aerosol (15 mg/m3 silica, 6 h/d, 5d/wk, 116 d), and measurements of pulmonary inflammation, damage, and fibrosis were monitored throughout the study. We report (1) data demonstrating that the silica aerosol generation and exposure system produced a consistent silica aerosol of respirable size particles; (2) the time course of silica deposition in the lung; (3) calculations that demonstrate that the rats were not in pulmonary overload; (4) histopathological data demonstrating time-dependent enhancement of silica-induced alveolitis, epithelial hypertrophy and hyperplasia, alveolar lipoproteinosis, and pulmonary fibrosis in the absence of overload; and (5) biochemical data documenting the development of lipidosis, lung damage, and fibrosis.

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  2. Wang Liying, Scabilloni James F, Antonini James M, Castranova Vincent, Rojanasakul Yon, Roberts Jenny R, Zhang Zhuo, Mercer Robert R, Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats, Laboratory Investigation, 86, 5, 2006. Crossref

  3. Kawasaki Hajime, A mechanistic review of silica-induced inhalation toxicity, Inhalation Toxicology, 27, 8, 2015. Crossref

  4. Liao Chung-Min, Wu Bo-Chun, Cheng Yi-Hsien, You Shu-Han, Lin Yi-Jun, Hsieh Nan-Hung, Ceramics manufacturing contributes to ambient silica air pollution and burden of lung disease, Environmental Science and Pollution Research, 22, 19, 2015. Crossref

  5. Hu Shuiying, Zhao Hongwen, Yin Xuejun J., Ma Joseph K. H., Role of Mitochondria in Silica-Induced Apoptosis of Alveolar Macrophages: Inhibition of Apoptosis by Rhodamine 6g andN-acetyl-L-cysteine, Journal of Toxicology and Environmental Health, Part A, 70, 17, 2007. Crossref

  6. Hubbs Ann, Greskevitch Mark, Kuempel Eileen, Suarez Fernando, Toraason Mark, Abrasive Blasting Agents: Designing Studies to Evaluate Relative Risk, Journal of Toxicology and Environmental Health, Part A, 68, 11-12, 2005. Crossref

  7. Dankovic David, Kuempel Eileen, Wheeler Matthew, An Approach to Risk Assessment for TiO2, Inhalation Toxicology, 19, sup1, 2007. Crossref

  8. Gulumian M., Borm P. J. A., Vallyathan V., Castranova V., Donaldson K., Nelson G., Murray J., Mechanistically Identified Suitable Biomarkers of Exposure, Effect, and Susceptibility for Silicosis and Coal-Worker'S Pneumoconiosis: A Comprehensive Review, Journal of Toxicology and Environmental Health, Part B, 9, 5, 2006. Crossref

  9. Mossman Brooke T., Glenn Robert E., Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs), Critical Reviews in Toxicology, 43, 8, 2013. Crossref

  10. Battelli Lori A., Ghanem Mohamed M., Kashon Michael L., Barger Mark, Ma Jane Y. C., Simoskevitz Ricki L., Miles Philip R., Hubbs Ann F., Crystalline Silica is a Negative Modifier of Pulmonary Cytochrome P-4501A1 Induction, Journal of Toxicology and Environmental Health, Part A, 71, 8, 2008. Crossref

  11. Umbright Christina, Sellamuthu Rajendran, Roberts Jenny R., Young Shih-Houng, Richardson Diana, Schwegler-Berry Diane, McKinney Walter, Chen Bean, Gu Ja Kook, Kashon Michael, Joseph Pius, Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats, Journal of Toxicology and Environmental Health, Part A, 80, 23-24, 2017. Crossref

  12. Beamer Celine A., Seaver Benjamin P., Shepherd David M., Aryl Hydrocarbon Receptor (AhR) Regulates Silica-Induced Inflammation But Not Fibrosis, Toxicological Sciences, 126, 2, 2012. Crossref

  13. Porter Dale W., Millecchia Lyndell, Robinson Victor A., Hubbs Ann, Willard Patsy, Pack Donna, Ramsey Dawn, McLaurin Jeff, Khan Amir, Landsittel Douglas, Teass Alexander, Castranova Vincent, Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica, American Journal of Physiology-Lung Cellular and Molecular Physiology, 283, 2, 2002. Crossref

  14. Herbert Ronald A., Janardhan Kyathanahalli S., Pandiri Arun R., Cesta Mark F., Chen Vivian, Miller Rodney A., Lung, Pleura, and Mediastinum, in Boorman's Pathology of the Rat, 2018. Crossref

  15. Sellamuthu Rajendran, Umbright Christina, Roberts Jenny R., Young Shih-Houng, Richardson Diana, McKinney Walter, Chen Bean T., Li Shengqiao, Kashon Michael, Joseph Pius, Molecular mechanisms of pulmonary response progression in crystalline silica exposed rats, Inhalation Toxicology, 29, 2, 2017. Crossref

  16. Porter Dale W., Millecchia Lyndell L., Willard Patsy, Robinson Victor A., Ramsey Dawn, McLaurin Jeffery, Khan Amir, Brumbaugh Kurt, Beighley Christoper M., Teass Alexander, Castranova Vincent, Nitric Oxide and Reactive Oxygen Species Production Causes Progressive Damage in Rats after Cessation of Silica Inhalation, Toxicological Sciences, 90, 1, 2006. Crossref

  17. Boyles Matthew S. P., Brown David, Knox Jilly, Horobin Michael, Miller Mark R., Johnston Helinor J., Stone Vicki, Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools, Inhalation Toxicology, 30, 7-8, 2018. Crossref

  18. HUTYROVÁ Beáta, SMOLKOVÁ Petra, NAKLÁDALOVÁ Marie, TICHÝ Tomáš, KOLEK Vítězslav, Case of accelerated silicosis in a sandblaster, INDUSTRIAL HEALTH, 53, 2, 2015. Crossref

  19. Castranova Vincent, Porter Dale, Millecchia Lyndell, Ma Jane Y. C., Hubbs Ann F., Teass Alexander, Effect of inhaled crystalline silica in a rat model: Time course of pulmonary reactions, in Oxygen/Nitrogen Radicals: Cell Injury and Disease, 2002. Crossref

  20. Kawasaki Hajime, A review of the fate of inhaled α-quartz in the lungs of rats, Inhalation Toxicology, 31, 1, 2019. Crossref

  21. Bomhard Ernst M., Particle-induced Pulmonary Alveolar Proteinosis and Subsequent Inflammation and Fibrosis: A Toxicologic and Pathologic Review, Toxicologic Pathology, 45, 3, 2017. Crossref

  22. Stueckle Todd A., Davidson Donna C., Derk Ray, Kornberg Tiffany G., Battelli Lori, Friend Sherri, Orandle Marlene, Wagner Alixandra, Dinu Cerasela Zoica, Sierros Konstantinos A., Agarwal Sushant, Gupta Rakesh K., Rojanasakul Yon, Porter Dale W., Rojanasakul Liying, Short-Term Pulmonary Toxicity Assessment of Pre- and Post-incinerated Organomodified Nanoclay in Mice, ACS Nano, 12, 3, 2018. Crossref

  23. Hubbs Ann F., Mercer Robert R., Benkovic Stanley A., Harkema Jack, Sriram Krishnan, Schwegler-Berry Diane, Goravanahally Madhusudan P., Nurkiewicz Timothy R., Castranova Vincent, Sargent Linda M., Nanotoxicology—A Pathologist’s Perspective, Toxicologic Pathology, 39, 2, 2011. Crossref

  24. Li Yaqian, Jin Fuyu, Li Tian, Yang Xinyu, Cai Wenchen, Li Shifeng, Gao Xuemin, Mao Na, Liu Heliang, Xu Hong, Yang Fang, Minute Cellular Nodules as Early Lesions in Rats with Silica Exposure via Inhalation, Veterinary Sciences, 9, 6, 2022. Crossref

  25. Langley Raymond J., Kalra Roma, Mishra Neerad C., Hahn Fletcher F., Razani-Boroujerdi Seddigheh, Singh Shashi P., Benson Janet M., Peña-Philippides Juan Carlos, Barr Edward B., Sopori Mohan L., A Biphasic Response to Silica, American Journal of Respiratory Cell and Molecular Biology, 30, 6, 2004. Crossref

  26. Lacourt Aude, Gramond Céline, Audignon Sabyne, Ducamp Stéphane, Févotte Joelle, Soit Ilg Annabelle Gilg, Goldberg Marcel, Imbernon Ellen, Brochard Patrick, Pleural Mesothelioma and Occupational Coexposure to Asbestos, Mineral Wool, and Silica, American Journal of Respiratory and Critical Care Medicine, 187, 9, 2013. Crossref

  27. Albrecht Catrin, Schins Roel P. F., Höhr Doris, Becker Andrea, Shi Tingming, Knaapen Ad M., Borm Paul J. A., Inflammatory Time Course after Quartz Instillation, American Journal of Respiratory Cell and Molecular Biology, 31, 3, 2004. Crossref

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