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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.15 5-Year IF: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v24.i4.50
pages 281-290

Gastric Glassy Cells: A Study of 3202 Gastrectomy Specimens from Dwellers of the Atlantic and Pacific Basins

Carlos Rubio
Departments of Pathology of Karolinska Institute and University Hospital, Stockholm, Sweden
K. Mandai
Departments of Pathology of National Shikoku Cancer Center Hospital, Matsuyama, Japan
J. G. Jonasson
Departments of Pathology of Reykjavik University, Reykjavik, Iceland
A. King
Departments of Pathology of Middlemore Hospital, Otahuhu, New Zealand
G. Nesi
Universitá Degli Studi di Fırenze, Florence, Italy
Z. Kogan
Hospital Municipal de Gastroenterologia, Buenos Aires, Argentina
R. Pisano
Hospital Jaraquemada, Santiago, Chile
M. Miller
Molecular Genetics, Biochemistry, Microbiology, and Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
D. Owen
Departments of Pathology of University of British Columbia, Vancouver, Canada


Fifteen years ago we detected gastric cells with glassy cytoplasm (GCs) in the human pyloric antrum. The frequency of these cells was subsequently investigated in sections from gastrectomies carried on in populations dwelling on the rim of the Atlantic and Pacific basins. In this work we compared the results obtained in these disparate geographic regions. We reviewed sections from 3203 gastrectomies (1942 in the Atlantic basin and 1261 in the Pacific basin). In the Atlantic basin 12/1942 (0.6%) of the gastrectomies had GCs, whereas in the Pacific basin 26/1261 (2.1%) of the gastrectomies had GCs. The difference was significant (p<0.05). The proportion of gastrectomies with GCs was higher in patients in Vancouver, Canada, than in New York, and higher in Santiago de Chile than in Buenos Aires, despite the fact that these populations reside at approximately the same geographic latitude. Previous studies with the same material indicated that both the extension of intestinal metaplasia and the frequency of ciliated metaplasia were significantly higher in the Pacific than in the Atlantic basin. Hence, the difference in the frequencies of GCs appears to be a new indication that dissimilar environmental exposures in the two basins might have influenced the histological make-up of the gastric mucosa.

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