Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology

Impact factor: 1.246

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2015014168
pages 321-334

Different Advanced Therapeutic Approaches to Treat Vitiligo

Chandra Kant Sharma
Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India
Coordinator at University level.
Monika Sharma
Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India
Bhawna Aggarwal
Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India
Vinay Sharma
Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India 304022

ABSTRACT

Vitiligo is a hypopigmentation disorder that is caused by the loss of melanocyte activity for melanin pigment generation. Vitiligo is distinguished by the existence of white macules. Vitiligo affects 0.1%−2% of individuals of different populations, irrespective of skin color, ethnic origin, race, or age. Although the actual mechanism behind this disease is not yet known, it is thought to be caused by a cumulative effect of various mechanisms (e.g., neurohormonal, genetic, cytotoxic, oxidative stress, autoimmune, and biochemical). This article reviews the published literature on various treatment modalities that might be effective in successfully treating patients with vitiligo, including phototherapies or some photochemotherapies, vitamin D analogs, topical and systemic corticosteroids, zinc treatment, anti-tumor necrosis factor agents, calcineurin inhibitors (tacrolimus, pimecrolimus), and surgical methods. This critical review also discusses a few herbal medications that may be worthy of future investigation because they have no significant side effects.