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Nanoscience and Technology: An International Journal
ESCI SJR: 1.031 SNIP: 1.517 CiteScore™: 0.7

ISSN Print: 2572-4258
ISSN Online: 2572-4266

Nanoscience and Technology: An International Journal

Formerly Known as Nanomechanics Science and Technology: An International Journal

DOI: 10.1615/NanomechanicsSciTechnolIntJ.v6.i4.50
pages 305-317

SYNTHESIS OF MICRO- AND NANOSIZED BIORESORBING SILICON-SUBSTITUTED TRICALCIUM PHOSPHATES FOR BONE TISSUE ENGINEERING AND THEIR BIOLOGICAL SAFETY USING MESENCHYMAL STEM CELLS

I. V. Fadeeva
Federal State Budgetary Scientific Institution "A. A. Baikov Institute of Metallurgy and Material Science", Russian Academy of Sciences, Russia
Ya. Yu. Filippov
Institute of Mechanics, Federal State Budgetary Higher Educational Institution "M. V. Lomonosov Moscow State University", Moscow, Russia
A. S. Fomin
Federal State Budgetary Scientific Institution "A. A. Baikov Institute of Metallurgy and Material Science", Russian Academy of Sciences, Russia
M. E. Shaposhnikov
Federal State Budgetary Scientific Institution "A. A. Baikov Institute of Metallurgy and Material Science", Russian Academy of Sciences, Russia
G. A. Davydova
Federal State Budgetary Scientific Institution "Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences", Russia
O. S. Antonova
Federal State Budgetary Scientific Institution "A. A. Baikov Institute of Metallurgy and Material Science", Russian Academy of Sciences, Russia
I. I. Selezneva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
A. Yu. Mikheev
Federal State Budgetary Scientific Institution "Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences", Russia
L. I. Akhmetov
Federal State Budgetary Scientific Institution "G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms", Russia
S. M. Barinov
Federal State Budgetary Scientific Institution "A. A. Baikov Institute of Metallurgy and Material Science", Russian Academy of Sciences, Russia
E. I. Zaraisky
Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, Russia
R. A. Poltavtseva
Federal State Budgetary Institution "Academician V. I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia

ABSTRACT

Silicon-substituted tricalcium phosphates have been developed by the precipitation method and heterophase mechanic activation using tetraethoxysilan as a source of silicate ions. The phase composition was established to depend on the silicate concentration: the apatite phase is formed at 0.09 wt.% silicate and Whitlockite is formed when the silicate concentration increases 10 times − up to 0.90 wt.%. The inhomogeneity and surface roughness of the material increase with the silicate concentration. Increasing the content of silicon in synthesized TCPs increases their thermal stability. Ceramics from silicon-substituted TCPs does not manifest cytotoxicity, while the cell spreading on the material surfaces increases with the degree of surface development, displaying the maximum value for the TCP sample with Si 0.1 substitution. The TCP ceramics containing 0.9 wt.% silicate ions characterize a pronounced antibacterial activity to E. Coli strain, whereas ceramics from TCPs do not manifest antibacterial activity.


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