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Nanoscience and Technology: An International Journal

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The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.7 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.7 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.11 SJR: 0.244 SNIP: 0.521 CiteScore™:: 3.6 H-Index: 14

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A REVIEW ON RECENT ADVANCEMENTS IN THE HEMODYNAMICS OF NANO-DRUG DELIVERY SYSTEMS

Volume 11, Issue 1, 2020, pp. 73-98
DOI: 10.1615/NanoSciTechnolIntJ.2020033448
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ABSTRACT

Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in developed countries. CVD is produced by atherosclerotic lesions that reduce arterial lumen size through plaque formation and arterial thickening. This decreases blood flow to the heart and frequently manifests itself in severe hemodynamic complications like myocardial infarction or angina pectoris. A drug delivery system (DDS) is a clinical methodology (formulation or device) that enables the introduction of a therapeutic substance into the body and improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body. Drug delivery technologies modify drug release profile, absorption, distribution, and elimination for the benefit of improving product effectiveness and patient convenience and compliance. The review extensively explores hemody-namic aspects of the cardiovascular system and diseases that can be treated via nano-drug delivery with a comprehensive overview of research efforts in these areas. Nanomedicine is an expeditiously growing science in which biomaterials (drugs) engineered at the nanoscale are implemented to enhance therapeutic performance and improve patient treatments. Among the many other diverse applications of nanomaterials in medicine (e.g., biotribology, tissue repair, orthopedic implants, etc.), nano-drug delivery systems have emerged as among the most promising ones. This technology has evolved into a significant platform for delivering successfully remedial agents to diseased sites with substantially greater target control, precision, and sophistication. By greatly increasing site-specificity, lowering toxicity, and target-oriented delivery, nanotechnological drug delivery (nanopharmacodynamics) has consistently achieved very impressive consistency, benefits and has aided massively in the fight against potentially lethal hematological diseases. Recently, nanomedicine has embraced an even wider range of applications including the administration of chemotherapeutic agents, biological agents, diabetes regulation, sterilization, cancer and tumor inhibition, rheumatic fever mitigation, etc. The current review presents a comprehensive appraisal of nano-drug delivery systems, simulation with engineering methods, types of nanodrugs and their effectiveness. The excellent targeting properties attainable with magnetic nanoparticles as engineering pharmacodynamic agents, in particular, offer huge potential in the treatment of many complex hemodynamic disorders. Furthermore, the present review summarizes the efficiency of drug carrier nanoparticles in mitigating the adverse effects of stenosed blood vessels and outlines other future potential uses for nano-drugs in biomedical applications.

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