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Nanoscience and Technology: An International Journal
ESCI SJR: 0.228 SNIP: 0.484 CiteScore™: 0.37

ISSN Print: 2572-4258
ISSN Online: 2572-4266

Nanoscience and Technology: An International Journal

Formerly Known as Nanomechanics Science and Technology: An International Journal

DOI: 10.1615/NanomechanicsSciTechnolIntJ.v7.i3.20
pages 235-246

CITRATE-STABILIZED NANOPARTICLES OF CeO2 STIMULATE PROLIFERATION OF HUMAN MESENCHYMAL STEM CELLS IN VITRO

A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
A. M. Ermakov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
I. V. Savintseva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
I. I. Selezneva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
R. A. Poltavtseva
Federal State Budgetary Institution "Academician V. I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia
E. I. Zaraisky
Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, Russia
A. M. Poltavtsev
Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, Russia
A. A. Stepanov
Research Institute of Human Morphology, Moscow, Russia
V. K. Ivanov
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
G. T. Sukhikh
Federal State Budget Institution "Academician V. I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology," Russian Ministry of Health, Moscow, Russia

ABSTRACT

Application of mesenchymal stem cells (MSCs) is one of the most prospective approaches in recovery of damaged organs. Currently, several reasons underlie the limitations of wide clinical use of human MSCs, including their low proliferation rate in vitro. In account of this, searching for new safe and efficient proliferation inducers is an urgent task. In the present study, we investigated the influence of citrate-stabilized cerium oxide (CeO2) nanoparticles on the proliferative activity of human MSCs. Introduction of CeO2 nanoparticles in MSC culture was shown to result in an intensification of cell proliferation rate in a dose-dependent manner. The conducted analysis of the transcription profile of human MSCs in the presence of CeO2 nanoparticles confirmed an increased transcription level for mRNAs of genes responsible for proliferation and cell cycle, as well as suppression of apoptosis. The derived results clearly indicate that CeO2 nanoparticles can be used as a basis for developing highly efficient inexpensive supplement for cell culturing in vitro.


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