Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Print: 2151-8017
ISSN Online: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2016018178
pages 1-15

Probiotics and Innate and Adaptive Immune Responses in Premature Infants

Mark A. Underwood
School of Medicine, University of California at Davis, Sacramento, CA

ABSTRACT

Premature infants are at increased risk for morbidity and mortality due to necrotizing enterocolitis (NEC) and sepsis. Probiotics decrease the risk of NEC and death in premature infants; however, mechanisms of action are unclear. A wide variety of probiotic species have been evaluated for potential beneficial properties in vitro, in animal models, and in clinical trials of premature infants. Although there is variation by species and even strain, common mechanisms of protection include attenuation of intestinal inflammation, apoptosis, dysmotility, permeability, supplanting other gut microbes through production of bacteriocins, and more effective use of available nutrients. Here, we review the most promising probiotics and what is known about their impact on the innate and adaptive immune response.


Articles with similar content:

Gut Microbiota: Potential Impact on Chemotherapy-Related Adverse and Therapeutic Effects
Forum on Immunopathological Diseases and Therapeutics, Vol.7, 2016, issue 1-2
M. Salimon, E. Montassier, Yann Touchefeu
Insulin Resistance and Tendinopathy
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.27, 2015, issue 1
Craig R. Denegar, Adrian Barniak, Michael F. Joseph, Ted Fifield
CD4+ T Lymphocytes Subsets in Early Life: Does Exclusive Breastfeeding Promote Allergy?
Critical Reviews™ in Immunology, Vol.39, 2019, issue 3
Fernanda Scherer Adami, Ramatis Birnfeld de Oliveira, Augusto Lengler Konrath, André Anjos da Silva, Ioná Carreno
Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease
Critical Reviews™ in Immunology, Vol.38, 2018, issue 5
Shiwa Soukou, Tanja Bedke, Leonie Brockmann, Nicola Gagliani, Samuel Huber, Richard A. Flavell
Regulation of Airway Innate and Adaptive Immune Responses: The IL-17 Paradigm
Critical Reviews™ in Immunology, Vol.28, 2008, issue 4
Sharlene Velichko, Reen Wu, Philip Thai, Li-Yin Hung, Fei Huang